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A new twist in metabolic T cell exhaustion

A new twist in metabolic T cell exhaustion

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DOI	10.1097/IN9.0000000000000080
刊名	Immunometabolism IJ
年，卷(期)	2026, 8(2)
作者	Aliazis, Konstantinos; Boussiotis, Vassiliki A.,
作者单位	Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
摘要	Metabolic reprogramming of T lymphocytes has a decisive role in their activation, differentiation, and functional fate commitment. Metabolic reprogramming guides not only the generation of T effector and T memory cells but also the development of dysfunctional exhausted (TEX) cells. A recent study by Haku et al published in Nature Immunology provides new insights into the role of mitochondria in regulating the metabolic capabilities of TEX cells and their implications for antitumor immunity.
Abstract	Metabolic reprogramming of T lymphocytes has a decisive role in their activation, differentiation, and functional fate commitment. Metabolic reprogramming guides not only the generation of T effector and T memory cells but also the development of dysfunctional exhausted (TEX) cells. A recent study by Haku et al published in Nature Immunology provides new insights into the role of mitochondria in regulating the metabolic capabilities of TEX cells and their implications for antitumor immunity.
关键词	cancer immunotherapy; T cell exhaustion; checkpoints; programmed cell death protein 1; metabolism
KeyWord	cancer immunotherapy; T cell exhaustion; checkpoints; programmed cell death protein 1; metabolism
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引用本文

Aliazis, Konstantinos; Boussiotis, Vassiliki A.. A new twist in metabolic T cell exhaustion [J]. Immunometabolism. 2026; 8; (2). - .

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