Reprogramming the diseased liver: antioxidant-engineered mRNA nanoparticles as microenvironment modulators in MAFLD-Immunometabolism-CSCIED科技核心评价数据库-手机版

Reprogramming the diseased liver: antioxidant-engineered mRNA nanoparticles as microenvironment modulators in MAFLD

Reprogramming the diseased liver: antioxidant-engineered mRNA nanoparticles as microenvironment modulators in MAFLD

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DOI	10.1097/IN9.0000000000000083
刊名	Immunometabolism IJ
年，卷(期)	2026, 8(2)
作者	Ghiringhelli, Matteo; Zangi, Lior,
作者单位	Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
摘要	Metabolic dysfunction–associated fatty liver disease (MAFLD) is a leading cause of hepatocellular carcinoma (HCC), driven in part by oxidative stress–induced immune dysfunction that limits the efficacy of immunotherapy. In a recent study, Yu et al developed a vitamin E–incorporated lipid nanoparticle designed to enhance hepatocyte‑specific mRNA delivery while simultaneously buffering oxidative stress in the hepatic microenvironment. By restoring the activity of the redox‑sensitive phosphatase T‑cell protein tyrosine phosphatase and suppressing signal transducer and activator of transcription (STAT) signaling, this strategy improves metabolic homeostasis, reduces inflammatory signaling, and enhances responsiveness to immune checkpoint blockade. These findings illustrate how rational nanoparticle engineering can integrate therapeutic delivery with microenvironmental reprogramming in chronic metabolic disease.
Abstract	Metabolic dysfunction–associated fatty liver disease (MAFLD) is a leading cause of hepatocellular carcinoma (HCC), driven in part by oxidative stress–induced immune dysfunction that limits the efficacy of immunotherapy. In a recent study, Yu et al developed a vitamin E–incorporated lipid nanoparticle designed to enhance hepatocyte‑specific mRNA delivery while simultaneously buffering oxidative stress in the hepatic microenvironment. By restoring the activity of the redox‑sensitive phosphatase T‑cell protein tyrosine phosphatase and suppressing signal transducer and activator of transcription (STAT) signaling, this strategy improves metabolic homeostasis, reduces inflammatory signaling, and enhances responsiveness to immune checkpoint blockade. These findings illustrate how rational nanoparticle engineering can integrate therapeutic delivery with microenvironmental reprogramming in chronic metabolic disease.
关键词	MAFLD; mRNA therapeutics; lipid nanoparticles; TCPTP; STAT signaling; oxidative stress; hepatocellular carcinoma; immune microenvironment
KeyWord	MAFLD; mRNA therapeutics; lipid nanoparticles; TCPTP; STAT signaling; oxidative stress; hepatocellular carcinoma; immune microenvironment
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引用本文

Ghiringhelli, Matteo; Zangi, Lior. Reprogramming the diseased liver: antioxidant-engineered mRNA nanoparticles as microenvironment modulators in MAFLD [J]. Immunometabolism. 2026; 8; (2). - .

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