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Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity

Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity

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DOI	10.1097/IN9.0000000000000054
刊名	Immunometabolism IJ
年，卷(期)	2025, 7(1)
作者	Vijayakumar, Anitha; Vasudevan, Sekar; John, Samu; Ozbun, Michelle A.; Bartee, Eric; Palanisamy, Viswanathan,
作者单位	Univ New Mexico, Dept Internal Med, Div Mol Med, Albuquerque, NM 87106 USA
摘要	The oral epithelium, a dynamic interface constantly facing environmental challenges, relies on intricate molecular pathways to maintain its homeostasis. This comprehensive review delves into the nuanced interplay between T-lymphocytic cells (T cells) and RNA-binding proteins (RBPs) within the oral epithelium, elucidating their roles in orchestrating immune responses and influencing tissue plasticity. By synthesizing current knowledge, we aim to unravel the molecular intricacies that govern this interplay, with a focus on potential therapeutic implications for oral health and diseases. Understanding the regulatory networks shaped by T cells and RBPs in the oral epithelial microenvironment holds promise for innovative strategies in managing conditions associated with epithelial dysfunction.
Abstract	The oral epithelium, a dynamic interface constantly facing environmental challenges, relies on intricate molecular pathways to maintain its homeostasis. This comprehensive review delves into the nuanced interplay between T-lymphocytic cells (T cells) and RNA-binding proteins (RBPs) within the oral epithelium, elucidating their roles in orchestrating immune responses and influencing tissue plasticity. By synthesizing current knowledge, we aim to unravel the molecular intricacies that govern this interplay, with a focus on potential therapeutic implications for oral health and diseases. Understanding the regulatory networks shaped by T cells and RBPs in the oral epithelial microenvironment holds promise for innovative strategies in managing conditions associated with epithelial dysfunction.
关键词	oral squamous cell carcinoma; post-transcriptional gene regulation; RNA-binding protein; post-translational protein modification; immune cells and tumor microenvironment
KeyWord	oral squamous cell carcinoma; post-transcriptional gene regulation; RNA-binding protein; post-translational protein modification; immune cells and tumor microenvironment
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Vijayakumar, Anitha; Vasudevan, Sekar; John, Samu; Ozbun, Michelle A.; Bartee, Eric; Palanisamy, Viswanathan. Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity [J]. Immunometabolism. 2025; 7; (1). - .

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