Journal of International Psychiatry

【Abstract】 Objective: Discussing methylphenidate hydrochloride controlled releasing tablets combined with carbamazepine with central temporal spikes in children with benign epilepsy syndrome combined effect of hyperactivity. Method: 80 children with BECTs and ADHD, who were diagnosed and treated in our hospital from January 2011 to January 2016, were selected as the research object. All children were given carbamazepine for treatment. If the 6 month review of electroencephalogram (EEG) stability, the children were given hydrochloride controlled release tablets combined with carbamazepine for treatment. The improvement of attention and behavior in children, the situation of seizure before and after the treatment, adverse reaction and treatment effect were observed and compared. Result: The total effective rate of BECTs treatment was 70% (56/80) 3 months after carbamazepine treatment. 2 cases of children with epilepsy due to increased frequency of seizures stop treatment. After 6 months of treatment, the total effective rate was 92.73% (51/55) in 55 patients. The Conner child behavior questionnaire scores were significantly reduced after treatment. Conclusion: Combining carbamazepine and methylphenidate hydrochloride controlled releasing tablets, there could effectively control the clinical symptoms which BECTS and ADHD in children, and significantly improved the attention of children and their social function, and had certain clinical safety .

【Key words】methylphenidate hydrochloride controlled release tablets; carbamazepine; central temporal spikes; benign infantile epilepsy; hyperactive syndrome