| Abstract |
【Abstract】 Objective To observe the levels of serum galectin-3 and nerve growth factor (NGF) in patients with different severity levels of bipolar disorder (BD). Methods A total of 80 clinical data of BD patients who were diagnosed and treated in our hospital from December 2023 to December 2024 were retrospectively collected. According to the Hamilton Depression Scale-24 (HAMD-24) and Young Mania Rating Scale (YMRS), patients with BD were evaluated for their seizure status and divided into a depressive episode group (HAMD-24>8 points, n=36）、 The manic episode group (YMRS score>6, n=27) and the mixed episode group (HAMD-24>8 and YMRS>6, n=17）。 At the same time, the Clinical Global Impression Severity Scale (CGI-S) was used to assess the severity of BD patients, who were divided into mild group (1-2 points, n=40), moderate group (3-4 points, n=24), and severe group (5-7 points, n=16). Compare the levels of serum galectin-3 and NGF in patients with different seizure states and different severity levels of the disease, and conduct a correlation analysis on the relationship between the severity of the disease and the levels of serum galectin-3 and NGF in BD patients. Results The serum galectin-3 level of BD patients in the mixed seizure group was higher than that in the depressive seizure group and the manic seizure group, while the NGF level was lower than that in the depressive seizure group and the manic seizure group (P<0.05). The serum galectin-3 level of BD patients in the severe group was higher than that in the moderate group and the mild group, while the NGF level was lower than that in the moderate group and the mild group. Moreover, the serum galectin-3 level in the moderate group was higher than that in the mild group, and the NGF level was lower than that in the mild group (P<0.05). Correlation analysis indicated that the CGI-S score of BD patients was positively correlated with the serum galectin-3 level and negatively correlated with the NGF level (P<0.05). Conclusion The levels of serum galectin-3 and NGF can reflect different seizure states and severity of the disease in patients with BD, and the levels of serum galectin-3 and NGF are closely related to the severity of the disease.
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