Journal of International Psychiatry

【Abstract】 Objective To analyze the intervention effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) on schizophrenia patients with negative symptoms and language impairment.Methods A total of 156 patients with schizophrenia who exhibited negative symptoms and language impairment were enrolled between October 2023 and July 2025. Using a random number table, they were randomly assigned to either an observation group (n = 78) or a control group (n = 78).The control group received conventional antipsychotic medication and rehabilitation training such as social skills training, while the observation group was treated with additional high-frequency rTMS. Treatment efficacy, improvement in negative symptoms, language function, and adverse reactions were compared between the two groups.Results  The observation group demonstrated superior therapeutic efficacy compared to the control group (P < 0.05). After treatment, both groups showed reductions in the Positive and Negative Syndrome Scale (PANSS) negative subscore and the total Score on the Scale for the Assessment of Negative Symptoms (SANS), with a more significant reduction in the observation group (P < 0.05). Both groups also exhibited decreased Speech Handicap Index (SHI) scores, with a more pronounced reduction in the observation group (P < 0.05). The incidence of adverse reactions was comparable between the two groups (P > 0.05).Conclusion High-frequency rTMS demonstrates significant efficacy in treating schizophrenia patients with negative symptoms and language impairment, effectively alleviating negative symptoms, improving language function, and exhibiting a favorable safety profile.

【Key words】High-frequency repetitive transcranial magnetic stimulation; Schizophrenia; Negative symptoms; Language impairment