Journal of International Psychiatry

【Abstract】 Objective To analyze the efficacy of mindfulness-based stress reduction therapy combined with drospirosterone and ethinylestradiol on chronic pelvic pain (CPP) related to endometriosis (EMs) and comorbidities of anxiety symptoms. Methods A total of 132 patients with EMS-related CPP and comorbidities of anxiety symptoms who were diagnosed and treated in our hospital from January 2022 to January 2025 were included and observed. The patients were divided into the study group (treated with mindfulness-based stress reduction therapy combined with drospirosterone and ethinylestradiol, 66 cases) and the control group (treated with drospirosterone and ethinylestradiol, 66 cases) according to the random number table method. Record two sets of Hamilton Anxiety Scale (HAMA) scores, Hospital Anxiety and Depression Scale (HADS) scores, Visual Analog Scale (VAS) scores, and Endometriosis Health Profile 5 (EHP5) scores for patients with endometriosis. Results Compared to before the intervention, both groups showed a decrease in HAMA and HADS-A scores after the intervention, and the study group had a lower score (P<0.05). Compared to before the intervention, both groups showed a decrease in VAS scores after the intervention, and the study group had a lower score (P<0.05). Compared to before the intervention, both groups showed a decrease in EHP5 scores after the intervention, and the study group had a lower score (P<0.05). Conclusion Mindfulness-based stress reduction therapy combined with drospirosterone and ethinylestradiol can more effectively alleviate anxiety symptoms in patients with EMS-related CPP and comorbidities with anxiety symptoms, reduce pain intensity, and improve the quality of life of patients.

【Key words】Endometriosis; Chronic pelvic pain; Anxiety symptoms; Mindfulness-based Stress reduction therapy; Drospiroone and ethinylestradiol