5HTR2A基因多态性对精神分裂症患者阿立哌唑干预疗效的影响
The effect of 5HTR2A gene polymorphism on the intervention efficacy of aripiprazole in patients with schizophrenia
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| DOI |
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| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2026, 53(1) |
| 作者 |
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| 作者单位 |
石家庄市第八医院 精神科
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| 摘要 |
【摘要】 目的 分析5-羟色胺2A受体（5-hydroxytryptamine receptor 2A，5-HTR2A）基因多态性对精神分裂患者阿立哌唑干预效果的影响。方法 选取2022年6月～2024年7月本院收治的200例首发精神分裂症患者为研究对象，均在入院后对5-HTR2A基因rs6313、rs6311位点的等位基因进行检测，并采取阿立哌唑干预治疗8周，以阳性与阴性症状量表（Positive and Negative Syndrome Scale，PANSS）减分率评估疗效。比较rs6313和rs6311位点不同基因型患者PANSS减分率；比较rs6313和rs6311位点不同基因型患者锥体外系反应（extra pyramidal symptoms，EPS）发生情况。结果 rs6313位点T/C基因型患者阳性症状、阴性症状和一般病理的减分率均高于C/C、T/T基因型患者（P＜0.05）；T/T基因型患者一般病理的减分率高于C/C基因型患者（P＜0.05）；T/C、C/C、T/T基因型患者PANSS的总分减分率比较均无差异（P＞0.05）。rs6311位点G/G基因型患者阳性症状、阴性症状、一般病理的减分率均低于A/A、A/G基因型患者（P＜0.05）；A/G基因型患者阳性症状的减分率高于A/A基因型患者（P＜0.05）；A/A、A/G、G/G基因型患者PANSS的总分减分率比较均无差异（P＞0.05）。rs6313和rs6311位点不同基因型患者EPS发生率比较均无显著差异（P＞0.05）。结论 阿立哌唑的干预效果受5-HTR2A基因多态性的影响，且rs6313的T/C基因型、rs6311的A/G基因型患者治疗效果更好。
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| Abstract |
【Abstract】 Objective To analyze the impact of 5-hydroxytryptamine receptor 2A (5-HTR2A) gene polymorphism on the intervention effect of aripiprazole in patients with schizophrenia.Methods Selecting 200 first-episode schizophrenia patients admitted to our hospital from June 2022 to July 2024 as the research subjects, After admission, the alleles at positions rs6313 and rs6311 of the 5-HTR2A gene were detected, and aripiprazole intervention treatment was administered for 8 weeks, Evaluate the efficacy using the Positive and Negative Syndrome Scale (PANSS) score reduction rate. Compare the PANSS score reduction rates of patients with different genotypes at the rs6313 and rs6311 loci; Compare the occurrence of extrapyramidal symptoms (EPS) in patients with different genotypes of rs6313 and rs6311 loci.Results The reduction rates of positive symptoms, negative symptoms, and general pathology in patients with the rs6313 T/C genotype were higher than those in patients with the C/C and T/T genotypes (P<0.05); The general pathological score reduction rate of T/T genotype patients is higher than that of C/C genotype patients (P<0.05); There was no significant difference in the total score reduction rate of PANSS among patients with T/C, C/C, and T/T genotypes (P>0.05). The reduction rates of positive symptoms, negative symptoms, and general pathology in patients with rs6311 locus G/G genotype were lower than those in patients with A/A and A/G genotypes (P<0.05); The reduction rate of positive symptoms in patients with A/G genotype was higher than that in patients with A/A genotype (P<0.05); There was no significant difference in the total score reduction rate of PANSS among patients with A/A, A/G, and G/G genotypes (P>0.05). There was no significant difference in the incidence of EPS between patients with different genotypes of rs6313 and rs6311 loci (P>0.05).Conclusion The intervention effect of aripiprazole is influenced by the 5-HTR2A gene polymorphism, and the treatment effect is better in patients with the T/C genotype of rs6313 and the A/G genotype of rs6311.
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| 关键词 |
【关键词】 精神分裂症；阿立哌唑；5-羟色胺2A受体；基因多态性
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| KeyWord |
【Key words】 Schizophrenia; Aripiprazole; 5-hydroxytryptamine receptor 2A; Genetic polymorphism
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| 基金项目 |
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| 页码 |
44-47 |
李军涛.
5HTR2A基因多态性对精神分裂症患者阿立哌唑干预疗效的影响 [J].
国际精神病学杂志.
2026; 53; (1).
44 - 47.