Journal of International Psychiatry

Depression, a mental illness characterized by persistent low mood and loss of interest, is now widely recognized as one of the most pressing mental health problems. The pathogenesis of depression has not yet been clarified, and the clinic still relies mainly on symptomatic diagnosis and lacks objective biological indicators. Ferroptosis, as a new form of iron-dependent cell death, has made remarkable progress in the pathogenesis of depression in recent years, and many studies have found that ferroptosis detection indicators in depressive patients differ from those in healthy individuals. In this paper, the author would like to review the research progress of ferroptosis from three aspects: its molecular mechanism, pathological association with depression and potential therapeutic strategies.

Ferroptosis；Depression；Molecular mechanism；Biomarker；Targeted therapy