Journal of International Psychiatry

[Abstract] Objective To explore the therapeutic differences between risperidone combined with sodium valproate and lithium carbonate in the treatment of schizophrenia with aggressive behavior (SZ). Methods Ninety SZ patients with aggressive behavior from July 2020 to October 2023 were selected. They were randomly divided into the two groups using the number table method, both receiving treatment with risperidone. 45 cases in the control group were combined with sodium valproate, while 45 cases in the observation group were combined with lithium carbonate. The aggressive behavior, SZ related symptoms, and adverse reactions before and after treatment were compared. Results The scores of the Modified Over Aggression Scale (MOAS) significantly decreased in both groups after treatment, while the observation group had lower scores after treatment (P<0.05). After treatment, the SZ symptom scores in both groups significantly decreased, and the positive symptom scores in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in other scores (P>0.05); There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The combination of risperidone and lithium carbonate in the treatment of SZ with aggressive behavior is more effective in reducing aggressive behavior and positive symptoms compared to the combination of sodium valproate, and the safety of the two is comparable.

Key words Risperidone; Sodium Valproate; Lithium Carbonate; Accompanying Aggressive Behavior; Schizophrenia