| Abstract |
[Abstract] Objective To investigate the occurrence of QTc interval prolongation and clinical risk factors in stable schizophrenia (SZ). Methods A total of 154 patients with stable SZ were selected from June 2022 to October 2023 to observe whether QTc interval prolongation occurred during hospitalization for medication. Univariate analysis was used to compare the general information and medication use of patients with and without QTc interval prolongation. Multifactorial analysis was used to investigate the influencing factors of QTc interval prolongation. Results There were 34 cases of 154 patients with stable SZ, with an incidence rate of 22.08%. The differences in age, gender, disease duration, smoking, body mass index, comorbid metabolic syndrome, medication use, and blood potassium concentration between patients with and without QTc interval prolongation were statistically significant (P<0.05). The differences in blood calcium concentration, history of alcohol consumption, and family history of SZ between the two groups were not significant (P>0.05). Multifactorial analysis showed that age, comorbid metabolic syndrome, blood potassium concentration, female, and co-medication were the influencing factors for prolongation of QTc interval in stable SZ. Conclusion The incidence of QTc interval prolongation is higher during the stable phase of SZ, and older age, comorbid metabolic syndrome, and low blood potassium concentrations increase the risk of QTc interval prolongation.
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