Journal of International Psychiatry

[Abstract] Objective To investigate the levels and clinical significance of T-cell subsets in patients with first-episode schizophrenia. Methods Eighty patients with first-episode schizophrenia and 80 healthy medical checkups from January 2022 to December 2022 were selected as the study subjects, and were divided into the observation group and the control group. Flow cytometry was used to detect serum CD3+, CD4+, and CD8+ levels in the subjects of both groups, and CD4+/CD8+ was calculated. Positive and negative syndrome scale (PANSS) was assessed in the observation group. The correlation between T-cell subset levels and PANSS was analyzed. Results The CD3+ and CD4+ levels of the observation group were lower than those of the control group, the CD8+ level was higher than that of the control group, and the CD4+/CD8+ was lower than that of the control group (P<0.05). There was a negative correlation between CD3+, CD4+ levels, CD4+/CD8+ and PANSS scores in the patients of the observation group, and there was no significant correlation between CD8+ levels (P<0.05). Conclusion Patients with first-episode schizophrenia have certain imbalances in T-lymphocyte subsets, and immune dysfunction may be involved in the onset and progression of first-episode schizophrenia.

Key words Primary Schizophrenia; T-Cell Subsets; Immune Function