重复经颅磁刺激合并小剂量帕罗西汀对躯体形式障碍的安全性和有效性研究

Repetitive transcranial magnetic stimulation combined with small dose paroxetine the safety and efficacy study of somatoform disorder

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2018, 45(1)
作者
作者单位

济宁市精神病防治院 ;

摘要
[摘要]目的:研究重复经颅磁刺激合并小剂量帕罗西汀对躯体形式障碍的安全性和有效性。 方法:选择2015年10月至2016年10月在我院接受治疗的躯体形式障碍患者100例,按照随机抽签的方式将其分为观察组和对照组,给予观察组患者使用重复经颅磁刺激合并小剂量帕罗西汀进行治疗,对照组患者则单纯使用小剂量帕罗西汀进行治疗,在治疗2周、3周后,观察两组患者HAMD、HAMA评分的变化,并观察其疗效以及不良反应。结果:治疗后,观察组的总有效率为88%,明显的高于对照组的总有效率68%,两组比较差异具有统计学意义(P<0.05);治疗2周后,观察组的HAMD与HAMA评分均显著的低于对照组评分[(13.35±3.12)分VS(16.75±3.32),(15.45±3.14)分VS(19.65±2.78)分];治疗3周后,观察组的HAMD与HAMA评分均显著的低于对照组评分[(7.85±2.89)分VS(11.45±3.18),(7.23±2.07)分VS(12.45±2.148)分],两组比较差异具有统计学意义(P<0.05);治疗后观察组不良反应总发生率为24%,明显的低于对照组的不良反应总发生率44%(P<0.05)。结论:使用重复经颅磁刺激合并小剂量帕罗西汀治疗躯体形式障碍患者,能够显著提高其治疗疗效,且起效快,安全性高,值得在临床上使用。
Abstract
[Abstract] Objective: To study the repetitive transcranial magnetic stimulation combined with small dose paroxetine safety and efficacy of somatoform disorder. Methods:200 patients with somatoform disorders from October 2015 to October 2015 in our hospital, according to the random lottery will be divided into the observation group and the control group and observation group patients use of repetitive transcranial magnetic stimulation combined with small dose paroxetine treatment, while the control group patients only use small dose paroxetine treatment, after treatment for 2 weeks, 3 weeks, then observe the changes of two groups of patients with HAMD, HAMA scores, and observe its curative effect and adverse reactions. Results: After treatment, the observation group total effective rate was 88%, significantly higher than that of control group 68%, there was statistically significant difference (P<0.05); 2 weeks after treatment, HAMD and HAMA score in observation group were significantly lower than the control group score [(13.35±3.12) VS (16.75±3.32), (15.45±3.14) VS (19.65±2.78)]. 3 weeks after treatment, HAMD and HAMA score in observation group were significantly lower than the control group score [(7.85±2.89) VS (11.45±3.18), (7.23±2.07) VS (12.45±2.148)], there was statistically significant difference (P < 0.05); Adverse reactions after treatment group total incidence was 24%, significantly lower than the control group 44% (P<0.05). Conclusion: The use of repetitive transcranial magnetic stimulation combined with small dose paroxetine in the treatment of somatoform disorders, can significantly improve the treatment curative effect, and take effect quickly, high safety, is worth in clinical use.
关键词
重复经颅磁刺激;帕罗西汀;躯体形式障碍
KeyWord
repetitive transcranial magnetic stimulation.;Paroxetine.;Somatoform disorders
基金项目
页码 84-87
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党现炳*. 重复经颅磁刺激合并小剂量帕罗西汀对躯体形式障碍的安全性和有效性研究 [J]. 国际精神病学杂志. 2018; 45; (1). 84 - 87.

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