Journal of International Psychiatry

[Abstract] Objective To explore the effects of electrolyte and lipid glucose metabolism on the prolongation of QTc interval during antipsychotic drug treatment in schizophrenia. Methods Eighty patients with schizophrenia were included in our hospital from March 2021 to February 2024. Among them, 27 patients experienced QTc interval extension and were set as the extension group, while 53 patients did not have extension and were set as the non extension group. Two groups of general information, electrolyte and lipid glucose metabolism, and analyze their impact on QTc interval extension through multiple factors were compared. Results The difference in medication use and disease course between the two groups was statistically significant (P<0.05). while there was no statistically significant difference in gender and age (P>0.05). The proportion of patients with hyperlipidemia and hyperglycemia in the extended group was higher than that in the non extended group, and the blood potassium concentration was lower than that in the non extended group (P<0.05). There was no statistically significant difference in blood calcium and magnesium concentrations between the two groups (P>0.05). Multivariate analysis showed that two drugs, hyperlipidemia, hyperglycemia, and blood potassium concentration were the influencing factors for QTc interval extension. Conclusion During the treatment of antipsychotic drugs for schizophrenia, abnormal electrocardiogram changes such as prolonged QTc interval are prone to occur, which may be induced by high blood lipids, blood sugar, low blood potassium.

Key words Electrolyte; Lipose Metabolism; Schizophrenia; QTc Interval Extension