不同抑郁障碍程度患者性激素、C反应蛋白表达水平及与5-HT、OFQ的相关性
Expression levels of sex hormone and C-reactive protein and their correlation with 5-HT and OFQ in patients with different degrees of depressive disorder
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| DOI |
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| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2025, 52(2) |
| 作者 |
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| 作者单位 |
开滦精神卫生中心
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| 摘要 |
目的：分析不同抑郁障碍程度患者性激素、C反应蛋白（C-reactive protein，CRP）表达水平及与5-羟色胺（5-hydroxytryptamine，5-HT）、孤啡肽（orphanin FQ，OFQ）的相关性。方法：选择于医院治疗的124例抑郁障碍患者，2020年11月-2023年11月病例入组，记为抑郁障碍组。选择同时期于本院体检的124例健康志愿者为健康组，检测两组患者血清雌二醇（Estradiol，E2）、睾酮（Testosterone，T）、5-HT、CRP、血浆OFQ水平，比较两组男性、女性E2、T水平；比较两组CRP、OFQ、5-HT水平；比较不同抑郁程度患者OFQ、5-HT表达水平；分析抑郁症患者OFQ、5-HT表达水平与抑郁程度的相关性。结果：抑郁障碍组E2、T、5-HT水平较健康组低（P＜0.05），CRP、OFQ水平高于健康组（P＜0.05）；重度抑郁5-HT水平较轻度抑郁及中度抑郁低（P＜0.05），OFQ表达水平较轻度抑郁及中度抑郁高（P＜0.05）；中度抑郁患者5-HT水平较轻度抑郁低（P＜0.05），OFQ表达水平较轻度抑郁高（P＜0.05）；抑郁障碍患者5-HT表达水平与抑郁程度呈负相关性（P<0.05），OFQ表达水平与抑郁程度呈正相关性（P<0.05）。结论：E2、T、5-HT水平在抑郁症患者机体中低表达，CRP、OFQ水平呈高表达，5-HT与抑郁程度呈负相关，OFQ与抑郁程度呈正相关。
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| Abstract |
Objective: To analyze the expression levels of sex hormone and C-reactive protein (CRP) and their correlation with 5-hydroxytryptamine (5-HT) and norphenkephalin (OFQ) in patients with different depressive disorder.Methods: A total of 124 patients with depressive disorder who were treated in the hospital were selected and enrolled from November 2020 to November 2023 and recorded as the depressive disorder group. A total of 124 healthy volunteers who underwent physical examination in our hospital at the same time were selected as the healthy group. Serum estradiol (E2), testosterone (T), 5-HT, CRP and plasma OFQ levels of the two groups were detected, and E2 and T levels of male and female in the two groups were compared. The levels of CRP, OFQ and 5-HT were compared between the two groups. The expression levels of OFQ and 5-HT in patients with different depression were compared. To analyze the correlation between the expression levels of OFQ and 5-HT and the degree of depression.Results: The levels of E2, T and 5-HT in depressive disorder group were lower than those in healthy group (P < 0.05), and the levels of CRP and OFQ were higher than those in healthy group (P < 0.05). The 5-HT level in major depression was lower than that in mild depression and moderate depression (P < 0.05), and the OFQ expression level was higher than that in mild depression and moderate depression (P < 0.05). The level of 5-HT in patients with moderate depression was lower than that in patients with mild depression (P < 0.05), and the level of OFQ was higher than that in patients with mild depression (P < 0.05). The expression level of 5-HT was negatively correlated with depression degree (P<0.05), and the expression level of OFQ was positively correlated with depression degree (P<0.05).Conclusion: The levels of E2, T and 5-HT are low in patients with depression, while the levels of CRP and OFQ are high. 5-HT is negatively correlated with the degree of depression, and OFQ is positively correlated with the degree of depression.
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| 关键词 |
关键词：抑郁症；孤啡肽；性激素；C 反应蛋白；5-羟色胺
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| KeyWord |
Key words: depression; Norkephalin; Sex hormone; C-reactive protein; Serotonin
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| 基金项目 |
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| 页码 |
441-444 |
陈薇, 侯建春, 孙妍.
不同抑郁障碍程度患者性激素、C反应蛋白表达水平及与5-HT、OFQ的相关性 [J].
国际精神病学杂志.
2025; 52; (2).
441 - 444.