Journal of International Psychiatry

Abstract: Objective To explore the correlation between cognitive function and sleep-wake parameters in patients with depression. Method Eighty-five depressed patients February 2022-March 2024 were included. The patients' cognitive functioning was assessed using the Mini-mental state examination (MMSE) scale. Sleep-wake parameter were recorded using sleep electroencephalograph. Sleep-wake parameter were compared between patients in the cognitive dysfunction group as well as in the group without cognitive dysfunction. Spearman's analysis was done to correlate the MMSE scores with the sleep-wake parameter of the patients in the cognitive dysfunction group. Result Twenty-seven of the 85 depressed patients had cognitive impairment, and all of them had mild cognitive impairment. MMSE score, Total sleep time（TST)、Sleep efficiency (SE)、Rapid eye nlovenlent（REM） were significantly lower in cognitive impairment group than in the group without cognitive impairment, and Sleep onset latency(SOL), number of awakenings and time were higher in cognitive impairment group than in the group without cognitive impairment (P<0.05). Spearman's analysis showed that MMSE scores in the cognitive impairment group were positively correlated with TST, SE, and REM, and negatively correlated with SOL, number of awakenings, and time (P<0.05). Conclusion Patients with depression are prone to cognitive impairment, and patients with cognitive impairment have shorter sleep time, more awakening time and times, and sleep-wake parameters are significantly correlated with cognitive function.

Key words Depression; Sleep-wake Parameter; Sleep Quality; Cognitive Function; Cognitive Impairment