| 摘要 |
【摘要】 探讨晚期宫颈癌患者焦虑抑郁状态的发生情况及其对常见化疗相关副反应的影响，探讨焦虑情绪对患者免疫功能的影响。方法 将80例宫颈癌化疗患者均进行GAD-7项的焦虑量表和和PHQ-9抑郁量表评分，于化疗后进行骨髓及消化道毒性反应评级，并进行免疫功能检测。结果 GAD-7量表测定：化疗前焦虑患者30例，占37.5%；化疗后34例，占42.5%；PHQ-9测定：化疗前抑郁患者33例，占41.3%；化疗后36例，占45.0%，化疗后患者焦虑、抑郁发生率均有增加趋势，但无统计学差异。焦虑、抑郁与非焦虑、抑郁宫颈癌患者化疗期间对比,焦虑、抑郁患者中重度消化道毒性发生率有显著性差异。而骨髓毒性无统计学差异。化疗后共有22例GAD-7及PHQ-9均大于6分者，与无抑郁焦虑或单纯抑郁、焦虑者比较，伴焦虑抑郁组T淋巴细胞亚群中CD3, CD4, CD8的细胞百分率较低,CD16+56、 CD4/CD8比值较高, 而且CD3、CD8、两组比较具有统计学意义(P<0.05)。结论 焦虑抑郁是宫颈癌患者普遍存在的症状, 化疗后患者焦虑和抑郁发生率有增加趋势，中重度消化道反应加重，合并焦虑抑郁患者免疫功能降低。应加强化疗患者不良反应预防、治疗和心理护理。
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| Abstract |
【Abstract 】 Objective To investigate the occurrence of anxiety depression in patients with advanced cervical cancer and its impact on the toxic and side effects of chemotherapy, to explore the influence of the immune function of patients. Methods 80 cases of cervical cancer patients were scored with chemotherapy GAD- 7 anxiety scale and PHQ -9 depression rating scale, were evaluated about the bone marrow and gastrointestinal tract toxicity reaction after chemotherapy and the immune function. Result GAD - 7 scale measurement results: before chemotherapy 30 cases patients with anxiety, accounted for 37.5%; After chemotherapy, 34 cases patients with anxiety, about 42.5%; PHQ - 9 scale measurement results :33 cases of depression patients before chemotherapy, accounted for 41.3%; After chemotherapy ,36 cases, accounting for45.0%, after chemotherapy, patients have increased incidence of anxiety and depression, but no statistical difference.The patients with anxiety and depression had the more severe incidences of gastrointestinal toxicity compared with the ordinary patients .The bone marrow toxicity incidences had no statistical difference. About 22 cases of GAD - 7 and PHQ - 9 were greater than 6 points, compared with the no depression anxiety ,the T lymphocyte subsets CD3, CD4, CD8 cell percentage was low, CD16 + 56, The ratio of CD4 / CD8 was higher, and CD3 and CD8, two groups of comparisons had statistical significance (P < 0.05). Conclusion anxiety depression is common symptoms, after chemotherapy the anxiety and depression incidence rate has increased, moderately severe gastrointestinal toxicity is aggravating, the immune function of patients with anxiety depression is low. we should strengthen the focus on Chemotherapy adverse reactions ,concluding :prevention, treatment and psychological care.
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