Journal of International Psychiatry

[Abstract]: Objective: To investigate the association between estrogen receptor-alpha (ESR1) gene polymorphisms and depressive symptoms among perimenopausal and post-menopausal women in Chinese Han population. Method: Four hundreds and thirty two women aged 45-55 were recruited from gynecological clinics of three hospitals in Shanghai city who were all in perimenopausal or postmenopausal period. Genotypes of SNP PvuII(rs2234693) and XbaI(rs9340799) on ESR1 gene were tested in these women. They also asked to finish our questionnaire including scales of BDI which were used to assess the quantity trait of depressive symptoms, and we also collected demographic data and obstetrics and gynecologyhistory data of them, KMI and SAS scales were used to assess the severity of anxiety and menopausal symptoms. Result: The XbaI polymorphism significantly associated with the BDI, the women with XX genotype is getting more serious depression symptoms than Xx and xx(Add value =1.85，95%CI=0.21～3.48). this result had adjusted by marital status. According to the PvuII polymorphism, it was not related to BDI in our study. Conclusion: The polymorphisms of ESR1 are associatied with severe depressive symptoms in perimemopausal and postmenopausal women in Han population of Chinese.

Estrogen receptor alpha; Genes; Depression; Menopause; Quantitative trait Loci