喹硫平与丙戊酸镁缓释片治疗双相障碍抑郁发作的对照研究
A comparison study of quetiapine and magnesium valproate sustained release tablets in the treatment of bipolar depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2018, 45(2) |
| 作者 |
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| 作者单位 |
山东省烟台市莱州荣军医院 ;
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| 摘要 |
【摘要】探讨喹硫平单药治疗双相情感障碍抑郁发作患者的临床疗效及安全性。方法 选取住院患者双相情感障碍抑郁发作患者61例，将其随机分为研究组和对照组两组，研究组（31例）予以喹硫平治疗，对照组（30例）予以丙戊酸镁缓释片治疗，为期8周，在治疗前及治疗后第1、2、4、8周末分别采用汉密尔顿抑郁量表（hamilton depression scale,HAMD-17）、阳性症状与阴性症状量表（positive and negative syndrome scale,PANSS）评定临床疗效，治疗副反应量表（treatment emergemt symptom scale,TESS）评定不良反应。结果 治疗前两组HAMD-17评分差异无统计学意义（P >0.05），在治疗后第2、4、8周研究组HAMD-17评分低于对照组，差异显著（P <0.05）；研究组患者PANSS量表评分在第2、4、8周PANSS评分低于对照组，差异有统计学意义（P <0.05）；研究组的不良反应发生率低。结论 喹硫平单药治疗双相情感障碍抑郁发作较丙戊酸镁缓释片临床疗效好，能有效改善患者的临床症状，且不良反应轻，安全性高。
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| Abstract |
【Abstract】Aim：To investigate the efficacy and safety of quetiapine therapy for bipolar depression.Methods：61 patients with bipolar depression were selected，the patients were randomly divided into two groups.The study group(31cases)was given quetiapine treatment. The control group(30 cases)was treated with magnesium valproate sustained release tablets. Two groups were taken for 8 weeks.The therapentic effects were assessed by hamilton depression scale(HAMD-17) and positive and negative syndrome scale(PANSS) before treatment and after treatment 1, 2, 4, 8 weekend. The adverse reactions were compared with treatment emergent symptom scale(TESS) .Results：After treatment second, 4, 8 weeks of group HAMD-17 was lower than the control group, the difference was significant (P<0.05); the study group patients with PANSS score at 2, 4, 8 weekend lower than the control group, the difference was statistically significant (P<0.05); the adverse reaction rate of the study group is low.Conclusion：Quetiapine can take satisfactory effect on bipolar depression with less side effects and high security,which can reduce improve the clinical symptoms.
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| 关键词 |
【关键词】喹硫平；丙戊酸镁缓释片；双相抑郁；疗效；安全性
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| KeyWord |
Key words:quetiapine; magnesium valproate sustained release tablets;bipolar depression;efficacy;safety
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| 基金项目 |
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| 页码 |
282-284 |
邹旭明*.
喹硫平与丙戊酸镁缓释片治疗双相障碍抑郁发作的对照研究 [J].
国际精神病学杂志.
2018; 45; (2).
282 - 284.