| Abstract |
Objective: To investigate the influence of maintenance dose DEX on postoperative cognitive function of senile patient with general anesthesia after gynecological operation. Methods: 92 senile patients with general anesthesia in our hospital from April 2014 to April 2016 were selected and divided into group A and group B, 46 cases in each group. Patients were all given same anesthesia induction and maintenance dose. Group A was given DEX intravenous infusion 0.8ug/kg and maintenance dose 0.5ug/（kg·h）. Group B was given intravenous infusion intravenous infusion. The NSE, IL-6, CRP, HMGB1, cognitive function and POCD occurrence rate at 24h before surgery, finish time, 24h, 3d, 7d after surgery and the adverse reactions between two groups were evaluated and compared. Results: (1) The levels of IL-6 and CRP in two groups at finish time, 24h, 3d, 7d after surgery were higher than those at before, The levels of group B at finish time, 24h, 3d after surgery was higher than those in group A, the difference was statistically significant (P<0.05); (2) The levels of NSE and HMGB1 in two groups at finish time, 24h, 3d after surgery were higher than those at before, the levels of NSE and HMGB1 of group B was higher than those in group A, the difference was statistically significant (P<0.05), HMGB1 declined 7h after surgery but still higher than it at before surgery, the levels of group B was higher than it in group A, the difference of the two groups was statistically significant (P<0.05); (4) the levels of MESS in two groups at 24h, 3d after surgery was declined, it declined more obviously in group B than that in group A, the difference was statistically significant (P<0.05). Conclusion: DEX can improve cognitive function of senile patients with general anesthesia after gynecological operation and can lower POCD occurrence rate. No severe adverse reactions occurred after surgery. DXE can be seen as a auxiliary anesthetic drug.
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