重复经颅磁刺激与抗抑郁药物及其联合治疗对产后抑郁患者认知功能及哺乳的影响
Effect of repetitive transcranial magnetic stimulation combined with antidepressant drugs on cognitive function and breast feeding of patients with postpartum depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2018, 45(2) |
| 作者 |
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| 作者单位 |
新疆自治区人民医院临床心理科 ;
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| 摘要 |
摘要：分析单用重复经颅磁刺激、抗抑郁药物及其联合治疗产后抑郁的临床效果。方法 将120例产后抑郁患者按随机数余数法分为A（氟西汀治疗）、B（重复经颅磁刺激治疗）、C组（氟西汀+重复经颅磁刺激治疗）各40例，比较三组治疗效果及认知功能改善情况，分析不同疗法对患者产后泌乳的影响。结果 ①治疗10周，三组分类数增加，B、C组随机错误数（RE）减少，C组持续错误数（PE）减少，B、C组分类数高于A组，RE低于A组，C组PE、RE均低于B组，其分类数高于B组（P<0.05）；②治疗10周，三组汉密尔顿抑郁量表评分（HAMD）、爱丁堡产后抑郁量表（EPDS）、睡眠效率、睡眠障碍、睡眠质量、日间功能评分均降低（P<0.05），B、C组降低幅度高于A组，C组降低幅度又高于B组（P<0.05）；③C组泌乳量少所占比例低于A组，泌乳量多所占比例高于A组（P<0.05）。结论 采用重复经颅磁刺激联合抗抑郁药物治疗产后抑郁症患者，可明显改善患者认知功能、睡眠质量及抑郁状，且对产后泌乳影响小。
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| Abstract |
Abstract: Objective To analyze the clinical effects of alone and combined use of repetitive transcranial magnetic stimulation and antidepressant drugs in the treatment of postpartum depression. Methods 120 cases with postpartum depression were randomly divided into group A (treated with fluoxetine), group B (treated with repetitive transcranial magnetic stimulation) and group C (fluoxetine + repetitive transcranial magnetic stimulation), with 40 cases in each group. The treatment effect and the improvement of cognitive function were compared between groups, and the effect of different therapies on postpartum lactation was analyzed. Results: ① After 10 weeks of treatment, the classification numbers in all groups increased, the random errors (RE) in group B and group C decreased and persistent errors (PE) in group C decreased. The classification numbers in group B and group C were larger than those in group A, RE was lower than that in group A, PE and RE in group C were lower than those in group B, and the classification number was larger than that in group B (P<0.05). ② After 10 weeks of treatment, the scores of Hamilton Depression Scale (HAMD) and the Edinburgh postnatal depression scale (EPDS), sleep efficiency, sleep disorders, sleep quality and daytime function were decreased (P<0.05), and the decreased ranges in group B and group C were lower than those in group A group, while the decreased ranges in group C were significantly and higher than those in group B (P<0.05). ③The proportion of low lactation yield in group C was lower than that in group A while the proportion of high lactation yield was higher (P<0.05). Conclusion The application of repetitive transcranial magnetic stimulation combined with antidepressant drugs in the treatment of postpartum depression can significantly improve the cognitive function, sleep quality and relieve depression, and the effect on postpartum lactation is little.
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| 关键词 |
关键词：产后抑郁；氟西汀；重复经颅磁刺激；泌乳；认知
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| KeyWord |
Key words: Postpartum depression; Fluoxetine; Repetitive transcranial magnetic stimulation; Lactation; Cognition
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| 基金项目 |
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| 页码 |
323-326 |
张义*.
重复经颅磁刺激与抗抑郁药物及其联合治疗对产后抑郁患者认知功能及哺乳的影响 [J].
国际精神病学杂志.
2018; 45; (2).
323 - 326.