善思达对精神分裂症患者急性期治疗的临床疗效和安全性

The clinical efficacy and safety of the good guy in schizophrenia patients with acute treatment

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2017, 44(3)
作者
作者单位

重庆市九龙坡区精神卫生中心 ;
解放军第324医院 ;
重庆市精神卫生中心 ;

摘要
【摘要】目的探讨采用棕榈酸帕利哌酮(善思达)治疗精神分裂症急性期患者的临床疗效及安全性。方法选取2014年6月至2016年6月在我院住院治疗的80例精神分裂症急性期患者,采用SAS10.0软件生成随机数字分为善思达组、利培酮组各40例,对比两组的临床效果。结果治疗2周、6周时,善思达组患者的PANSS总分、阳性症状量表、阴性症状量表评分均低于同期利培酮组患者(P<0.05);治疗6周后,善思达组患者的痊愈率40.00%、显效率47.50%、进步12.50%,利培酮组分别为27.50%、37.50%、30.00%,两组比较差异具有统计学意义(P<0.05);治疗6周后,善思达组的血清催乳素水平低于利培酮组(P<0.05);善思达组的不良反应发生率22.50%低于利培酮组的50.00%(χ2=6.545,P=0.011<0.05)。结论善思达治疗精神分裂症急性期患者疗效较好,安全性较高。
Abstract
【Abstract】Objective To investigate the clinical efficacy and safety of the treatment of patients with schizophrenia in acute stage with the use of Paley (a) of palm acid. Methods From June 2014 to June 2016 in our hospital 80 cases of mental patients with schizophrenia in acute phase, synthesis of randomly divided into good star group, risperidone group of 40 cases by SAS10.0 software, compared the clinical effects of two groups.Results 2 weeks and 6 weeks of treatment, good star group of patients with PANSS score, positive symptom scale, negative symptom scale scores were lower than the same period of risperidone group (P<0.05); after 6 weeks of treatment, the good guy group the cure rate was 40%, markedly effective rate of 47.50%, progress 12.50%, respectively, 27.50% in risperidone group 37.50%, 30%, two groups had significant difference (P<0.05); after 6 weeks of treatment, good star group of serum prolactin levels lower than the risperidone group (P<0.05); the adverse reactions of good star formation rate of 22.50% is lower than the risperidone group 50% (χ2=6.545, P=0.011<0.05). Conclusion Now the good treatment effect of schizophrenia patients with better, higher security.
关键词
【关键词】棕榈酸帕利哌酮;精神分裂症;急性期;安全性
KeyWord
【Key words】Palmitic acid peary pp ketone; Schizophrenia; The acute phase; security
基金项目
页码 427-429
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龚昌富,贺英,王捷*,覃晓玲,刘亚. 善思达对精神分裂症患者急性期治疗的临床疗效和安全性 [J]. 国际精神病学杂志. 2017; 44; (3). 427 - 429.

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