Journal of International Psychiatry

【Abstract】 Objective To compare the clinical efficacy and safety of quetiapine and aripiprazole in treatment of schizophrenia (SCH) patients with hypertensive. Methods Totally 92 cases of SCH patients with hypertensive admitted in our hospital from March 2014 to March 2016 were collected and divided into group A and B group according to the method of random number table, each group with 46 patients. The patients in group A were treated with quetiapine,while patients in group B were treatment with aripiprazole.The positive and negative syndrome scale (PANSS), 24h average systolic blood pressure (24h SBP), 24h average diastolic blood pressure (24h DBP), 24h systolic pressure variation (24h SSD) diastolic blood pressure variation and 24h (24hDSD) were evaluated before and after treatment in both groups,the Treatment Emergent Symptom Scale (TESS) score side effects between the two groups were compared.Results 8 weeks After treatment, the levels of SBP and DBP in the both groups were significantly decreased,and the group A were significantly lower than those in the group B (P<0.05). After treatment, the scores of PANSS and each factor were significantly decreased (P<0.05),but there were no significant differences between the two groups (P<0.05);The TESS score in group A was significantly lower than that in group B (P<0.05),and the incidence of side effects was 28.26% in group A,significantly lower than 56.52% in group B (P<0.05).Conclusion Quetiapine and aripiprazole show similar efficacy in the treatment of SCH patients with hypertensive,but the quetiapine has better effect of auxiliary blood pressure and less side effects.It may be preferred for such patients

【Key words】 Schizophrenia; Hypertension; Quetiapine; Aripiprazole; Efficacy; Safety