Journal of International Psychiatry

Abstract: Objective: To observe the impact analysis of Shuganjieyu Capsules in treatment of patients with schizophrenia with chronic insomnia of index sleep and mental state. Methods: 100 patients with schizophrenia with chronic insomnia were retrospectively analyzed from April 2014 - May2016 from in hospital, according to the dosing methods ,all patients were divided into experimental group (n=50) and control group(n=50). The control group was given O set sent azole（15mg/time，1time/d）and alprazolam tablets（0.8mg/time，1time/d）. Experimental group was given O set sent azole（15mg/time，1time/d）and was gived Shuganjieyu capsules(2 grain /time，1time/d),two groups of treatment of 6 weeks.The Pittsburgh sleep quality index (Pittsbuigh sleep quality index, PSQI) to evaluate patients sleep quality.The brief psychiatric scale (BPRS) to evaluate patients mental state.Compared two groups of patients clinical curative effect, PSQI scores before and after the treatment, PSQI scores before and after the treatment, and adverse reactions occur.Results: Total effective rate of of experimental group was higher than the control group after treatment with statistical significance.PSQI per item score and total score of experimental group were lower than the control group after treatment with statistical significance.BPRS per item score and total score of experimental group were lower than the control group after treatment with statistical significance.During treatment , two groups of adverse reactions were no statistical significance. Conclusion: Shuganjieyu capsules can effectively improve clinical curative effect in patients with schizophrenia with long-term insomnia that improve sleep quality, improve the mental state, and high safety, which is worth further clinical application.

Keywords: Shuganjieyu Capsules；schizophrenia ； chronic insomnia；Sleep index；mental state