| Abstract |
Abstract: Objective To analyze the relationship between PANSS, Nesfatin-1 and nerve function defect degree in depressive degree of patients with acute cerebral stroke. Methods 160 patients with acute stroke were selected randomly in our hospital from May 2014 to May 2016. They were divided into depression group and non depression group by post-stroke depression. The nerve function defect degree, depressive degree, PANSS and Nesfatin-1 levels was diagnosed, and the relationship between factors and depressive degree was analyzed. Results The incidence of post-stroke depression was 46.25% (n = 74), 54.05%（40/74) of them were slightly depressed, 28.38% (21/74) of them were moderately depressed, and 17.57% (13/74) of them were severely depressed. The incidence of obesity, negative syndrome, spectacular downfall, lesion location, NIHSS and Nesfatin-1 in patients with different degree depression had significant difference (P<0.05). The scores of NIHSS, negative syndrome and spectacular downfall in severe depression group was significantly higher than that in non depression, mild and Moderate depression group(P<0.05). By multiple factor analysis, negative syndrome, spectacular downfall, lesion location, NIHSS and Nesfatin-1 was closely related to depression severity of acute stroke patients (P<0.05). Conclusion The incidence rate of acute stroke patients with depression after stroke is high, mostly in moderate and mild. Negative syndrome, spectacular downfall, lesion location, NIHSS and Nesfatin-1 was closely related to depression severity of acute stroke patients. The early prevention and intervention should be took to reduce the severity of post-stroke depression in the clinic.
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