Journal of International Psychiatry

【Abstract】 Objective To evaluate the influence of citalopram on short and long-term prognosis in patients with chronic heart failure (CHF) complicated with depression.Methods 120 patients with CHF complicated with depression were divided into two groups according to the therapy method: Patients of control group (n=60) received conventional anti-heart failure treatment,patients of observation group (n=60) received citalopram treatment on the basis of control group for 6 months.The clinical effect, heart function,Hamilton Depression Scale (HAMD) and Minnesota Heart Failure Quality of Life Questionnaire (MLHFQ)score before and after treatment were compared between the two groups,the re-admission and all-cause mortality were counted. Results The total effective rate of cardiac function of observation group was 90.00%, significantly higher than 78.33% of control group (P<0.05); At the end of the one,six months after treatment,the HAMD score,MLHFQ score, Left Ventricular End Diameter Diastolic (LVEDD) and N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) of observation group were significantly lower than the control group (P<0.05),while the Left Ventricular Ejection Fraction (LVEF) and 6min Walking Distance (6 WMT) were significantly higher than the control group (P<0.05); At the end of the follow-up period,the re-admission and all-cause mortality were 38.89% and 9.26% of observation group respectively, significantly lower than 76.36%, 21.82% of control group (P<0.05). Conclusion The short-term efficacy of citalopram in the treatment of CHF omplicated with depression is exact,it can improve the patients depressive symptoms and quality of life,so as to improve cardiac function and long - term prognosis.

【Key words】 Chronic heart failure; Citalopram; Depression; Clinical prognosis