探讨烟酸缺乏症导致精神分裂症的病理机制

To investigate the pathologic mechanism of niacin deficiency in schizophrenia

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DOI 105015
刊名
Journal of International Psychiatry
年,卷(期) 2018, 45(2)
作者
作者单位

新疆医科大学第一附属医院心里医学中心 ;

摘要
烟酸缺乏症会出现多种精神症状,以往研究表明,烟酸强化治疗可用于精神分裂症。本文回顾三种烟酸缺乏症导致精神分裂症的病理机制:(1)烟酸缺乏导致神经退行性病变(2)烟酸缺乏造成膜磷脂不足假说(3)烟酸缺乏导致肾上腺素红蓄积假说,进一步探讨烟酸强化治疗精神分裂症。
Abstract
The niacin deficiency manifests with several psychiatric manifestations. And historically evidence has suggested that niacin augmentation treatment can be used in schizophrenia. We reviewed three of the pathological mechanisms in which niacin deficiency could lead to schizophrenic symptoms: (1) Niacin deficiency lead to neurodegeneration (2) Niacin deficiency lead to membrane phospholipid deficiency hypothesis (3) Niacin deficiency lead to adrenochrome accumulation hypothesis,to further investigate the niacin augmentation treatment of schizophrenia.
关键词
烟酸缺乏症;精神分裂症;病理机制;烟酸强化治疗
KeyWord
niacin deficiency;schizophrenia;pathological mechanisms;niacin augmentation treatment
基金项目
页码 205-207
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瞿莹颖,伊琦忠*,杜雯,罗晓,孙乐乐,安治国. 探讨烟酸缺乏症导致精神分裂症的病理机制 [J]. 国际精神病学杂志. 2018; 45; (2). 205 - 207.

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