Journal of International Psychiatry

[Abstract] Objective: To explore the relationship of mental health, personality and immune function of patients with generalized anxiety disorder. Methods: 56 cases of patients with generalized anxiety disorder (GAD) treated in our hospital were selected as the observation group, and 50 cases of health persons carried physical examination in the same period. Mental health and personality characteristics were evaluated in the two groups by using Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), and Eysenck Personality Questionnaire (EPQ-RSC) respectively, and serum interleukin-2 (IL-2), CD3+, natural killer cells (NK) were examined in the two groups, and the relationship of mental health, personality and immune function were analyzed in the observation group. Results: The items and total scores of SAS and SDS in the observation group were significantly higher than those in the control group (P < 0.05). There were no statistically significant differences in E, P, L scores between the observation group and the control group(P < 0.05). The total score of N and EPQ-RSC in the observation group were significantly higher than those of the control group (P < 0.05). IL-2 level in the observation group was significantly higher than that in the control group (P < 0.05), CD3＋and NK were significantly lower than those of the control group (P < 0.05). Analysis results showed SAS, SDS and EPQ-RSC were positively correlated with IL-2, and were negatively correlated with CD3＋and NK. Conclusion: Anxiety and depression in GAD patients are significantly higher than those in healthy subjects, with personality characteristics of neurotic tendency. It has a serious impact on immune function.

[Keywords] Generalized anxiety disorder; Mental health; Personality characteristics; Immunity；Correlation analysis