补肾填髓中药调控OPG/RANKL/RANK信号通路改善骨质疏松 大鼠骨密度的Meta分析

Meta-analysis of Chinese medicine for tonifying kidney and filling marrow to improve bone mineral density in rats with osteoporosis by regulating OPG/RANKL/RANK signaling pathway

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DOI 10.12208/j.ircm.20250001
刊名
International Research in Chinese Medicine
年,卷(期) 2025, 5(1)
作者
作者单位

吉首大学医学院 湖南吉首

摘要
目的 对补肾填髓中药治疗骨质疏松的临床疗效及安全性进行Meta分析和系统评价,为中医治疗骨质疏松症的疗效与机制提供更有可信度和准确性的结论和证据支持。方法 检索中国知识资源总库、维普中文期刊数据库、万方数据知识服务平台、Cochrane Library、PubMed、Embase 6个数据库中调控OPG/RANKL/RANK信号通路治疗骨质疏松的相关文献,检索时间为建库至2023年12月31日。采用GetDate Graph Digitizer软件、Rev Man 5.4.1软件、Cochrane偏倚风险评价工具进行图片数据提取、统计分析及文献质量评价。结果 本研究共纳入41篇文献,涉及933只大鼠。相较于对照组,补肾填髓中药干预组在提高骨密度和血清及骨组织OPG表达水平,降低血清及骨组织RANK、RANKL表达水平等方面差异显著(P<0.05)。结论 补肾填髓中药可通过调控OPG/RANK/RANKL信号通路来改善OP模型大鼠的骨代谢状态,但研究方案中干预方案、测量指标等不完全统一,可能存在潜在异质性。未来需要开展更多设计严谨、统计效能充足的高质量随机对照试验,以进一步增加动物实验结果的外推性和可复制性,并探索其临床应用价值。
Abstract
Objective Meta-analysis and systematic evaluation were conducted on the clinical efficacy and safety of Chinese medicine for tonifying kidney and filling marrow in the treatment of osteoporosis, so as to provide more credible and accurate conclusions and evidence support for the efficacy and mechanism of Chinese medicine in the treatment of osteoporosis. Methods The relevant literature on regulating OPG/RANKL/RANK signaling pathway for the treatment of osteoporosis was searched in 6 databases, including China National Knowledge Resource Database, VIP Chinese Journal Database, Wanfang Data Knowledge Service Platform, Cochrane Library, PubMed, and Embase. The search time was from the establishment of the database to December 31, 2023. GetDate Graph Digitizer software, Rev Man 5.4.1 software, and Cochrane bias risk assessment tool were used for image data extraction, statistical analysis, and literature quality evaluation. Results A total of 41 articles involving 933 rats were included in this study. Compared with the control group, the intervention group of tonifying kidney and filling marrow Chinese medicine had significant differences in improving bone mineral density and serum and bone tissue OPG expression levels, and reducing serum and bone tissue RANK and RANKL expression levels (P < 0.05). Conclusion tonifying kidney and filling marrow Chinese medicine can improve the bone metabolism state of OP model rats by regulating the OPG/RANK/RANKL signaling pathway, but the intervention scheme and measurement indicators in the research scheme are not completely unified, and there may be potential heterogeneity. In the future, more high-quality randomized controlled trials with rigorous design and sufficient statistical power are needed to further increase the extrapolation and replicability of animal experimental results and explore their clinical application value.
关键词
补肾填髓;中药;骨质疏松症;OPG/RANK/RANKL信号通路;系统评价
KeyWord
Tonifying kidney and filling marrow; Chinese medicine; Osteoporosis; OPG/RANK/RANKL signaling pathway; Systematic review
基金项目
页码 1-13
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刘昊斓, 张鹏, 赵任坤. 补肾填髓中药调控OPG/RANKL/RANK信号通路改善骨质疏松 大鼠骨密度的Meta分析 [J]. 国际中医药研究. 2025; 5; (1). 1 - 13.

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