International Journal of Clinical Research

Objective To investigate the clinical effect of amiodarone in the treatment of ventricular arrhythmias after acute myocardial infarction, and to evaluate its comprehensive value in controlling rhythm abnormalities. Methods A total of 97 patients with acute myocardial infarction and ventricular arrhythmia admitted to our hospital from January 2024 to January 2025 were selected and divided into 48 cases in the control group and 49 cases in the experimental group according to the random number table method. The control group received standardized conventional treatment, and the experimental group combined with intravenous and oral amiodarone on this basis. The two groups of patients were compared with the heart rhythm recovery time and other indicators. Results The heart rhythm recovery rate of the experimental group was 46.94% within 1 hour, which was higher than that of the control group(18.75%).The arrhythmia control rate was93.88%within 72 hours after treatment, which was better than that of the control group(66.67%).The increase of QT prolongation was 8.16% in the experimental group with more than 60 ms, and no fatal rhythm events were observed. The incidence of adverse reactions in the experimental group was 24.49%, which was slightly higher than that in the control group, but all were controllable mild to moderate events. The recurrence rate of severe ventricular arrhythmias during hospitalization was 6.12% in the experimental group, which was much lower than that of the control group (20.83%),and the difference was statistically significant (P<0.05). Conclusion Amiodarone intervention can improve the rhythm control efficiency and rhythm stability of ventricular arrhythmias after acute myocardial infarction, and has multiple advantages such as rapid onset and controllable risk, making it suitable for early clinical intervention.

Amiodarone; Acute myocardial infarction; Ventricular arrhythmias