| Abstract |
Objective To investigate the distribution characteristics and drug resistance of pathogens in patients with chronic obstructive pulmonary disease (COPD) combined with pulmonary tuberculosis, providing a basis for the rational selection of antimicrobial agents in clinical practice. Methods A retrospective study was conducted on 525 patients with COPD combined with pulmonary tuberculosis admitted to our hospital from January to December 2024. Pathogen detection and drug resistance data were analyzed using the χ² test and SPSS18 software. Results A total of 45 bacterial species were isolated, with the top three pathogens being Klebsiella pneumoniae (158 strains, 30%), Burkholderia cepacia (68 strains, 13%), and Acinetobacter baumannii (55 strains, 10%). Drug susceptibility analysis showed that Klebsiella pneumoniae was highly sensitive to meropenem (98.1%) and amikacin (98.7%), but less sensitive to cefazolin (73.4%); Burkholderia cepacia showed high sensitivity to cefotetan (91.2%) and meropenem (88.2%), but low sensitivity to levofloxacin (30.9%) and chloramphenicol (40.9%); Acinetobacter baumannii exhibited good sensitivity to polymyxin (94.5%) and gentamicin (87.3%), but extremely low sensitivity to ceftriaxone (1.82%). Conclusion In patients with COPD combined with pulmonary tuberculosis, the predominant pathogens are Klebsiella pneumoniae, Burkholderia cepacia, and Acinetobacter baumannii, with no significant differences in gender or age distribution. For these patients, certain bacterial strains show high sensitivity, and clinical drug susceptibility analysis along with pathogen identification can significantly help in the rational selection of antibiotics, clarify the causative pathogens, and reduce the emergence of resistant strains, offering valuable clinical implications.
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