| Abstract |
Abstract Objective To explore the influence of levodopa on the cognitive function and the levels of plasma Hcy, Vitamin B12 and folic acid in the treatment of elderly Parkinson’s disease (PD) patients. Methods 70 cases elderly PD patients in our hospital from Feb. 2015 to Apr. 2016 were elected as observation group, and 50 cases elderly healthy people in the same time were elected as control group, besides, the patients of observation group were divided randomly into low dose group (n=35) and high dose group (n=35), observation group were treated with levodopa for 6 months continuously. Evaluated the cognitive function by mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA), carried out language and the visual spatial working memory test for all patients before and after treatment; detected and compared the changes of plasma Hcy, Vitamin B12 and folic acid levels of control group and observation group, as well as before and after treatment in observation group. Results The MMSE and MoCA scores, the voice memory score, semantic memory scores, and the distance memory score, location memory score were lower than that of contyrol group before treatment (P<0.05 or P<0.01); the above indexes after treatment increased compared with before treatment, and except the MMSE and MoCA scores, voice memory score were lower than that of control group (P<0.05 or P<0.01), the others had no significant difference between 2 groups (P>0.05); The plasma Hcy level of observation group were higher than that of control group before treatment (P<0.01), while the Vitamin B12 and folic acid levels were lower than that of control group (P<0.05 or P<0.01); Compared with before treatment, the plasma Hcy level of low dose group and high dose group increased significantly, and high dose group was higher than lower dose group (P<0.01); the plasma Vitamin B12 level of low dose group and high dose group decreased significantly, and high dose group was lower than lower dose group (P<0.01); the plasma folic acid level of high dose group and low dose group had no significant changes (P>0.05). Conclusion Levodopa can improve the cognitive function of elderly PD patients to some extent, but which accompanied with plasma Hcy level increased and Vitamin B12 and folic acid levels decreased in the same time, and can increase the untoward effect, so we should strengthen the clinical nutrition adjuvant therapy of Vitamin B12 and folic acid.
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