丙泊酚和七氟烷麻醉对老年胸外科手术患者术后认知功能的影响分析
Effects of propofol and sevoflurane anesthesia on postoperative cognitive function in elderly patients undergoing Department of thoracic surgeryPengji,Zhenghan,Wangli,Yangxue
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2017, 44(5) |
| 作者 |
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| 作者单位 |
第三军医大学附属大坪医院 ;
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| 摘要 |
摘要：目的：探讨丙泊酚麻醉和七氟烷麻醉对老年胸外科手术患者术后认知功能的影响。方法：选择医院2015年6月-2016年6月收治的110例老年胸外科手术患者作为研究对象，按照数字表法随机分为观察组和对照组，每组各55例患者。观察组给予丙泊酚联合舒芬太尼麻醉，对照组给予七氟烷联合舒芬太尼麻醉，比较两组患者术后认知功能障碍发生率和对认知功能产生影响的因素进行分析。结果：两组患者手术时间和麻醉时间无明显差异（p>0.05）;观察组自主呼吸恢复时间、睁眼时间、拔管时间和应答时间均少于对照组（p<0.05）；术后1h,6h，12h观察组MMSE评分均高于对照组（p<0.05）,观察组术后12hMMSE评分恢复至术前水平，对照组术后24h恢复至术前水平。观察组术后不良反应发生率为14.55%，对照组不良反应发生率为30.91%，观察组明显低于对照组（p<0.05）；术后1h，6h，合并基础疾病患者POCD发生率明显高于无基础疾病患者。结论：丙泊酚和七氟烷麻醉都会导致老年胸外科手术患者术后短期内认知功能的下降，均会引起POCD的发生，但丙泊酚麻醉对认知功能的影响较小，术后认知功能恢复更早。
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| Abstract |
Abstract: Objective: To investigate the effect of propofol anesthesia and seven isoflurane anesthesia on postoperative cognitive function in elderly patients undergoing laparoscopic surgery.Methods: 110 cases of elderly patients with Department of thoracic surgery from June 2015 to group and control group, there were 55 patients in each group.The observation group was given propofol combined with sufentanil anesthesia, the control group was given seven halothane anesthesia with sufentanil and cognitive function were compared between two groups after operation.Results: Two groups of patients with operation time and anesthesia time had no significant difference (p>0.05); the observation group recovery time of spontaneous breathing, eye opening time, extubation time and response time were less than the control group (p<0.05);The MMSE scores of 1h, 6h and 12h after operation in the observation group were higher than those in the control group (p<0.05) , and after 12h ago , MMSE score of the observation group was restored to the preoperative level, and after 24h of the control group returned to the preoperative level.The patients in the observation group the incidence of adverse reaction was 14.55%, the control group adverse reaction rate was 30.91%, the observation group was significantly lower than the control group (p<0.05); after 1h, 6h, POCD in patients with underlying disease incidence was significantly higher than that in patients without underlying diseases.Conclusion: Propofol and sevoflurane anesthesia in seven will lead to the decline of the old Department of thoracic surgery postoperative cognitive function in the short term, there will cause POCD, but has little effect on the cognitive function of propofol anesthesia, earlier recovery of cognitive function after surgery.
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| 关键词 |
关键词：丙泊酚；七氟烷；麻醉；认知功能
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| KeyWord |
Key words: Propofol; seven halothane; anesthesia; cognitive function
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| 基金项目 |
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| 页码 |
934-936 |
彭霁,郑菡*,王丽,杨雪.
丙泊酚和七氟烷麻醉对老年胸外科手术患者术后认知功能的影响分析 [J].
国际精神病学杂志.
2017; 44; (5).
934 - 936.