| Abstract |
[Abstract] Objective: To study and discuss with ziprasidone sodium valproate for the treatment of bipolar disorder manic episode clinical effect. Methods: from January 2013 ~2017 year in March in our hospital for treatment of 100 patients with bipolar disorder manic patients as the research object, take the computer random number table method were randomly divided into control group and observation group, 50 patients in each group, the control combined with olanzapine in the treatment of patients with sodium valproate combined with ziprasidone in the treatment of observation, using sodium valproate group, after 8 weeks of treatment, the clinical curative effect of mania, compared two groups of patients with the score, the incidence of adverse reactions. Results: the clinical observation group, the total effective rate was 94%, clinical the control group the total efficiency is 78%, the two groups, the difference was statistically significant (P<0.05); after treatment, the two groups of patients with mania score was significantly lower than before treatment ( P<0.05), and the two groups were compared after treatment, patients with mania score were significantly lower than the control group (P<0.05); observation group of patients with adverse reaction rate was 4%, the control group of patients with adverse reaction rate was 18%, the two groups, the difference was statistically significant (P, <0.05). Conclusion: the ziprasidone and sodium valproate combined with bipolar disorder manic patients has obvious clinical curative effect of treatment, which can effectively alleviate the patients with manic symptoms, and can reduce the incidence of adverse reactions in patients, efficacy, safety and reliable.
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