上海市焦虑障碍首诊患者门诊药物联用现况调查

Present survey on prescription psychotropic drugs in the outpatients with anxiety outpatients in Shanghai

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2017, 44(6)
作者
作者单位

上海交通大学医学院附属精神卫生中心 ;

摘要
了解上海市精神病专科医院焦虑障碍患者首诊精神药物的使用现况。方法 对上海市精神卫生中心2010年1月至2015年12月门诊登记就诊的25,040例首诊的焦虑障碍患者病例资料进行回顾性分析。结果 (1)首诊的女性患者数量(59.6%)显著多于男性(40.4%),且年龄较大。(2)门诊焦虑障碍首诊药物治疗共使用17类具有抗焦虑作用的精神药物,其中排名前三位分别为5-羟色胺再摄取抑制剂(SSRI)、苯二氮卓类(BZDS)、去甲肾上腺素和特异性5-羟色胺受体拮抗剂(NaSSA)。(3)单一用药患者7716例,两药合并治疗患者9866例,三药以上合并治疗患者7458例,三者之间差异在统计学上显著(P<0.01),同时,在两药合并治疗中,各类具有抗焦虑作用的精神药物合并苯二氮卓类药物治疗显著少于合并非苯二氮卓类精神药物(P<0.01)。结论 上海市精神病专科医院对焦虑障碍首诊的药物治疗在遵守《中国焦虑障碍防治指南》建议的治疗原则基础上,平衡疗效和安全性,根据患者特点进行针对性用药。
Abstract
Objective To evaluate the use patterns of psychotropic drugs in treating outpatients with anxiety disorder. Methods A retrospective analysis was made of 25,040 cases of outpatients with anxiety disorder from January 2010 to December 2015 in Shanghai Mental Health Center. Results (1)The number of female patients(59.6%) was significantly higher than that of male(40.4%) and had a higher age. (2)Outpatient anxiety disorder first drug treatment using a total of 17 types of psychotropic drugs with anxiolytic effects, of which the top three were serotonin reuptake inhibitors(SSRI), benzodiazepine(BZDS), norepinephrine And specific serotonin receptor antagonists(NaSSA). (3)7,716 cases were treated with mono-pharmacy. 9,866 cases were treated with two kinds of drugs and 7,716 cases were treated with three or more drugs. The difference was statistically significant(P<0.01). In the combination therapy of two drugs, all kinds of psychotropic drugs combined with benzodiazepine drug treatment were significantly less than the combination of other psychotropic drugs. Conclusions Shanghai psychiatric hospital for the first intervention of anxiety treatment of drug treatment balance of efficacy and safety.
关键词
焦虑障碍;精神病专科门诊;首诊;药物治疗;现状
KeyWord
Anxiety disorder; Psychiatric specialist outpatient service; First treatment; Medical treatment; Investigation and analysis
基金项目
页码 1031-1034
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杨旭娇,宋立升*. 上海市焦虑障碍首诊患者门诊药物联用现况调查 [J]. 国际精神病学杂志. 2017; 44; (6). 1031 - 1034.

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