Journal of International Psychiatry

[Abstract] Objective To explore the relationship between hemodynamics changes of extracranial carotid artery and arterial stenosis in patients with chronic schizophrenia. Methods A total of 100 patients with chronic schizophrenia admitted in our hospital from June 2015 to June 2017 were selected for the study and divided into the observation group and the control group according to whether there was carotid artery stenosis. The extracranial carotid artery (CCA), internal carotid artery (ICA) and vertebral artery (VA) were examined by Doppler ultrasonography, and the hemodynamic differenceswere compared between the two groups. Results The peak systolic velocity (PSV) and end-diastolic velocity (EDV) of the extracranial arteries in the observation group were significantly decreased compared with those in the control group (P<0.05) while the resistance index (RI) was significantly increased compared with that in the control group (P<0.05). Moreover, the accuracy rate of anterior circulation stenosis by EDV prediction was the highest (76.7%) in ICA with the optimal cutoff value of 20.58 cm/s, and the accuracy rate of posterior circulation stenosis by EDV prediction was highest (80.4%) in VA with the optimal cutoff value of 10.19 cm/s. Conclusions Intracranial arterial stenosis in patients with chronic schizophrenia can cause extracranial carotid artery blood flow with "low speed and high resistance" change, and to a certain extent the change can be used to predict intracranial artery stenosis.

[Key Words] Extracranial carotid artery; Hemodynamics changes; Chronic schizophrenia; Intracranial arterial stenosis; Relationship