Journal of International Psychiatry

【Abstract】 Objective To investigate the effect of edaravone combined with ganglioside-1 (GM-1) on neurological function and cognitive function after surgery in patients with intracranial hemorrhage (ICH). Methods Eighty-four patients with ICH after surgery were randomly divided into observation group and control group,42 cases in each group. The control group was treated with edaravone, the observation group was supplemented with GM-1 on the basis of control group. The NIHSS score and the MoCA score were measured before and after treatment at 14 days ,28 days and 3 months after treatment,the serum levels of hs-CRP, IL-6, T-SOD,NSE and BDNF were measured. Results At 14 days, 28 days and 3 months after treatment,the NIHSS score in the observation group was significantly lower than that of the control group,while the MoCA score was significantly higher (P<0.05);At 28 days after treatment, the serum levels of hs-CRP, IL-6, NSE in the observation group were significantly lower than the control group,the levels of T-SOD and BDNF were significantly higher (P<0.05). Conclusion Edaravone combined with GM-1 can effectively promote the recovery of neurological function and protect cognitive function of ICH patients after surgery,its mechanism may be related to the regulation of neurological and inflammatory factors, antioxidant damage.

【Key words】 Intracranial hemorrhage; Edaravone; Ganglioside-1; Neurological function; Cognitive function