Journal of International Psychiatry

Abstract：Objective To investigate the influence of escitalopram assisted with tandospirone on negative mood status, laboratory indicators and cardiovascular events risk of elderly female patients with coronary heart disease secondary to anxiety and depression. Methods 100 elderly female patients with coronary heart disease secondary to anxiety and depression were chosen in the period from January 2014 to January 2016 in our hospital and randomly divided into both group including control group (50 patients) with tandospirone used alone and observation group (50 patients) with escitalopram assisted with tandospirone; and the clinical efficacy, the HAMD score, HAMA score, the levels of IL-18 and MPO before and after treatment, the incidence of cardiovascular events and adverse reaction of both groups were compared. Results The clinical total efficacy of observation group were significantly higher than control group（p<0.05）. The HAMD score and HAMA score of observation group after treatment were significantly lower than control group and before treatment（p<0.05）. The levels of IL-18 and MPO of observation group after treatment were significantly lower than control group and before treatment（p<0.05）. The incidence of cardiovascular events of observation group were significantly lower than control group and before treatment（p<0.05）. There was no significant difference in the adverse reaction incidence between 2 groups（p>0.05）. Conclusion Escitalopram assisted with tandospirone in the treatment of elderly female patients with coronary heart disease secondary to anxiety and depression can efficiently relieve the negative mood symptoms, regulate the levels of IL-18 and MPO levels, prevent the cardiovascular events occurrence and not increase the risk of adverse drug reactions.

escitalopram; tandospirone; elderly patients; female; coronary heart disease; anxiety and depression