| Abstract |
Abstract: Objective: To investigate the effect of repetitive transcranial magnetic stimulation (TMS) on depression, sleep and cognitive function in elderly patients with depression. Methods: 180 elderly patients with depression in our hospital from March 2015 to December -2016 were randomly divided into three groups. The three groups were given antidepressant treatment. 60 cases of senile depression patients with high frequency group, 10HZ high frequency, 90% cortical motor threshold stimulation of the left frontal lobe, 60 cases of elderly patients with depression and low frequency group, 1HZ low frequency, 90% cortical motor threshold stimulating right frontal lobe, the control group of 60 cases of elderly patients with depression, only using antidepressant drug therapy. After treatment with Hamilton depression scale, Beck Depression Scale (BDI), global assessment scale (GAF) and Pittsburgh sleep quality index (PSQI) to evaluate the antidepressant effect of patients, with the Wisconsin Card Sorting Test and continuous performance test evaluation of cognitive function in the patients of the two groups. Results: the low frequency group of elderly patients with depression after treatment, Hamilton Depression Scale score and total score were decreased and the global assessment scale score increased, Beck Depression Scale scores were lower, PSQI score were decreased compared with the control group, the difference was statistically significant (P<0.05). But the high frequency group and low frequency group after treatment in patients with Hamilton Depression Scale score and total score, global assessment scale, Beck depression scale and Pittsburgh sleep quality index score, the difference was not statistically significant (P>0.05). Compared the three groups before and after treatment in elderly patients with depression in Wisconsin Card Sorting Test total number, correct response the number and numbers of persistent error and random error number and classification of the project, there was no statistically significant difference (P>0.05). Repetitive transcranial magnetic Stimulation therapy did not affect patient cognitive ability. The three groups before and after treatment of senile depression patients with continuous performance test project and other projects compared to the last test compared the difference was not statistically significant (P>0.05). Conclusion: high frequency repetitive transcranial magnetic stimulation on the right side of the left side and the low frequency repetitive transcranial magnetic stimulation on depression in elderly patients with depression has better curative effect than single antidepressant treatment. Improve the depression mood and sleep disorders, and does not damage the cognitive function of patients, but low frequency repetitive transcranial magnetic stimulation showed no significant effect, both of which are of clinical value.
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