Journal of International Psychiatry

【Abstract】 Objective: To study the efficacy of fluoxetine in the treatment of elderly patients with anxiety and its effect on negative emotions and quality of life. Methods: A total of 118 elderly patients with anxiety were enrolled in our hospital from April 2016 to April 2017, and were randomly divided into observation group and control group (n = 59). Patients in the observation group were treated with fluoxetine and the control group received diazepam tablets. The total effective rate and the incidence of adverse reactions were compared between the two groups, and the anxiety scores and quality of life scores were compared between the two groups before and after treatment. Results: The total effective rate (86.4%) was significantly higher in the observation group than in the control group (64.4%) (P<0.05). After 8 weeks of treatment, the HAMA score of the observation group was significantly lower than that of the control group (P <0.01). The scores of health status, physical condition, general life, social psychological status and working status were significantly higher than those of the control group (P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: Fluoxetine is effective in the treatment of elderly patients with anxiety. It can obviously alleviate the symptoms of patients with anxiety and improve the quality of life, and the treatment is safe and worthy of popularization in clinical practice.

【Key words】Fluoxetine; elderly; anxiety; efficacy; quality of life