Journal of International Psychiatry

Abstract: Objective: To investigate the effect of dexmedetomidine on postoperative cognitive function in patients undergoing radical resection of esophageal carcinoma. Methods: 76 cases of radical resection of esophageal cancer patients were randomly divided into 2 groups, 38 cases in each group, two groups were given fentanyl intravenous analgesia, the control group for the first time, intravenous injection of midazolam 0.05mg/kg, followed by 0.02~0.08mg/kg.h-1 to maintain anesthesia, the observation group was intravenous infusion of dexmedetomidine 1 g/kg then to 02 ~ 0.7 g/kg.h-1 to maintain anesthesia, sedation occurred and adverse reaction were compared between the two groups. Results: the two groups of the sedative effect of time were no statistically significant difference compared (P>0.05); but the observation group after stopping the recovery time shorter than the control group (P<0.05); the incidence of adverse reactions was 13.16%, 39.47% lower than the control group, the difference was statistically significant (P<0.05). The observation group after treatment WCST total responses (50.44 + 5.92), persistent error number (13.71 + 2.11), non persistent error number (15.11 + 2.65) was significantly lower than the control group (P<0.05), correct responses (25.45 + 0.56), a complete classification number (5.17 + 0.24) was more than the control group. There was significant difference between two groups (P<0.05). Conclusion: Dexmedetomidine in general anesthesia for esophageal cancer sedation effect is good, can improve the cognitive function of patients, and reduce the incidence of adverse reactions, it is worth recommending.

Keywords Esophageal cancer radical resection; general anesthesia patients; dexmedetomidine; force month West; cognitive function