双相抑郁的细胞因子及自身免疫研究进展

Cytokines and Autoimmunity in Bipolar Depression: the research progress

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DOI R749.05
刊名
Journal of International Psychiatry
年,卷(期) 2018, 45(6)
作者
作者单位

上海交通大学医学院附属精神卫生中心 ;

摘要
双相障碍是一种患病率较高、复发率高的重性精神疾病。双相障碍的病因机制未明。既往研究发现,在中枢神经系统和免疫系统的相互作用下,双相障碍患者呈现慢性且复发加重的病程特点。由于双相障碍存在不同的发作阶段,并且在双相抑郁发作时的误诊率较高,因此双相障碍的细胞因子研究结果存在较大的异质性。本文旨在探讨双相抑郁细胞因子变化特点,以及其相关免疫机制。
Abstract
Bipolar disorder is a severe mental illness characterized of high rate of both prevalence and recurrence. The pathophysiological mechanism of bipolar disorder is still unknown. Previous studies found that the interaction between central nervous system and immune system results in the chronic and recurrent aggravating course of the bipolar disorder. Due to the different onset stages of bipolar disorder and the higher incidence of misdiagnosis in bipolar depression, the results of the study on the cytokines of bipolar disorder are of greater heterogeneity. The alterations of cytokines in bipolar depression were summarized to discuss the potential immune mechanism in this review.
关键词
双相抑郁;细胞因子;自身免疫
KeyWord
Bipolar Depression; Cytokines; Autoimmunity
基金项目
页码 968-970
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丁蕾,刘虹晔,张晨,彭代辉*. 双相抑郁的细胞因子及自身免疫研究进展 [J]. 国际精神病学杂志. 2018; 45; (6). 968 - 970.

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