选择性5-羟色胺再摄取抑制剂联合阿立哌唑治疗强迫性障碍对照研究Meta分析
Meta-analysis of comparative study of SSRI combined with aripiprazole in treating obsessive-compulsive
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2018, 45(3) |
| 作者 |
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| 作者单位 |
上饶市第三人民医院 ;
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| 摘要 |
评价选择性5-羟色胺再摄取抑制剂联合阿立哌唑治疗强迫性障碍的疗效和安全性。方法 检索中国期刊全文数据库、万方数据库、维普中文期刊中选择性5-羟色胺再摄取抑制剂联合阿立哌唑治疗强迫性障碍对照研究 (截止2017年5月)。以Jadad法对纳入文献进行质量评价，采用Review Manager5.0软件进行Meta分析。结果 共检索到相关论文24篇，实际纳入分析17篇，所有研究均未提及分配隐匿和盲法。累计病例数为979例，其中选择性5-羟色胺再摄取抑制剂联合阿立哌唑513例，单用选择性5-羟色胺再摄取抑制剂466例。选择性5-羟色胺再摄取抑制剂联合阿立哌唑治疗前后组内比较，加权平均效应d=-15.01，95%CI为-18.09～-11.93，有显著差异（Z =9.55，P <0.01）；选择性5-羟色胺再摄取抑制剂联合阿立哌唑与单用选择性5-羟色胺再摄取抑制剂治疗后组间比较，d=-3.58，95%CI为-4.62～-2.54，有显著差异（Z =6.77，P<0.01）。两组不良反应发生率无显著差异（χ2=0.04，P>0.05）。结论 选择性5-羟色胺再摄取抑制剂联合阿立哌唑能增强抗强迫疗效，不增加不良反应。
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| Abstract |
Objective To assess the efficacy of SSRI combined with aripiprazole in the treatment of obsessive-compulsive in China. Methods Related literatures about comparative study of SSRI combined with aripiprazole in treating obsessive-compulsive was searched in the Wanfang, CNKI database and CQVIP with closing date May 2017. The quality of included papers was evaluated by Jadad scale, and the meta-analysis was performed using Rev Man 5.0 software. Results Totally 24 papers were collected and finally 17 papers were included in the analysis. The cumulative number of cases was 979, 513 cases for SSRI combined with aripiprazole group and 466 cases for treated with SSRI. All of the studies did not mention the allocation concealment and blind method. There was significant difference in the efficacy before and after treatment with SSRI combined with aripiprazole（Z =9.55，P <0.01）, d=-15.01，95%CI-18.09～-11.93. There was significant difference in the efficacy between SSRI combined with aripiprazole and treated with SSRI after treatment（Z =6.77，P<0.01）, d=-3.58，95%CI-4.62～-2.54. There was no significant difference in the adverse drug reation rate between the two groups（χ2=0.04，P>0.05）. Conclusion SSRI combined with aripiprazole are more effective in treating obsessive-compulsive, there is no increase in adverse reactions.
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| 关键词 |
选择性5-羟色胺再摄取抑制剂；阿立哌唑；强迫性障碍；Meta分析
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| KeyWord |
SSRI；Aripiprazole；Obsessive-compulsive；Meta-analysis
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| 基金项目 |
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| 页码 |
437-440 |
徐琼*.
选择性5-羟色胺再摄取抑制剂联合阿立哌唑治疗强迫性障碍对照研究Meta分析 [J].
国际精神病学杂志.
2018; 45; (3).
437 - 440.