| Abstract |
【Abstract】Objective:To analyze the clinical expression of homocysteine (HCY), interleukin 6 (IL-6) and neutrophil-lymphocyte ratio (NLR) in patients with untreated first-episode schizophrenia (DUP). Risk factors.Methods:A total of 162 patients with DUP were included in this hospital from April 2012 to October 2015. Among them 104 patients were male patients. 162 patients were divided into two groups based on DUP time. Long DUP group (above 50W) 87 cases, short DUP group (less than or equal to 50W) 75 cases; automatic blood cell analyzer to detect serum lymphocyte count (LYM), white blood cell count (WBC), neutrophil count (NEU), lymphocyte percentage (LYM% ), Hemoglobin (HGB), Percent neutrophil (NEU%), and Hematocrit (HCT) were calculated, NLR ratios were calculated, serum HCY levels were measured by an automated biochemical analyzer, and serum IL-6 levels were measured by ELISA.Results: There was significant difference in marital status between short CUP group and long DUP group (P<0.05). The serum IL-6, HCY, NLR and PANSS scores of short DUP patients were lower than those of long DUP patients. Significance (P<0.05); Pearson correlation analysis showed that DUP and serum NLR, IL-6, HCY and PANSS scores were positively correlated (r=0.351, 0.786, 0.402, 0.908, P=0.010, 0.001, 0.003, 0.001); PANSS score was positively correlated with serum HCY and IL-6 (r=0.472, 0.783, P=0.001, 0.001); Logistic regression analysis showed that serum IL-6 was an independent risk factor for DUP.Conclusions:There are differences in psychopathological symptoms, ie inflammatory factors, between short DUP and long DUP patients. Serum NLR, IL-6, and HCY may be used as reference markers for determining the severity of schizophrenia.
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