抑郁症患者治疗前后抗炎性细胞因子的变化分析-国际精神病学杂志-CSCIED科技核心评价数据库-手机版

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抑郁症患者治疗前后抗炎性细胞因子的变化分析

The Changes of cytokine levels in patients with depression before and after treatment

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刊名	国际精神病学杂志 Journal of International Psychiatry
年，卷(期)	2018, 45(6)
作者	李露露*,
作者单位	天津市安定医院 ;
摘要	探讨抑郁症患者治疗前后细胞因子白细胞介素13（IL-13）、白细胞介素4（IL-4）、转化生长因子β1（TGF-β1）的变化。方法应用酶联免疫吸附方法（ELISA）测定抑郁症患者96例（病例组）经过艾司西酞普兰治疗前后IL-13、1L-4、TGF-β1的水平变化，与健康对照组90例（对照组）比较。结果病例组TGF-β1水平与对照组比较差异无统计学意义（P﹥0.05）。病例组IL-13、IL-4水平均低于对照组，差异有统计学意义（P﹤0.05）。治疗后，病例组IL-13、IL-4水平均高于治疗前，差异有统计学意义（P﹤0.05）。治疗后，病例组HAMD评分均低于治疗前，差异有统计学意义（P﹤0.05）。病例组治疗前后的IL-13、IL-4水平与 HAMD评分之间呈较强的负相关性（P﹤0.05）。结论抗炎性细胞因子水平降低可能与抑郁症发生发展相关，IL-13、IL-4水平对于临床上抗抑郁药物疗效的评价有一定的指导作用。
Abstract	Objective To investigate the changes of interleukin 13(IL-13), interleukin 4(IL-4) and transformed growth factor-β1 (TGF-β1) before and after depression treatment. Methods The levels of 1L-4, IL-13, TGF-β1 in 96patients with depression were measured by ELISA and compared with 90 controls. Results The levels of TGF-β1 in the case group was not significantly different from that in the control group (P>0.05). The level of IL-13 and IL-4 in the case group was significantly lower than those in the control group (P<0.05). After treatment, the level of IL-13 and IL-4 were significantly higher than before treatment(P<0.05). After treatment, HAMD scores were significantly lower than before treatment(P<0.05). There was a strong negative correlation between IL-13 and IL-4 levels and HAMD scores before and after treatment(P<0.05).Conclusion The decrease of anti inflammatory cytokines may be related to the development of depression, and the levels of IL-13 and IL-4 has a certain guiding role in the evaluation of clinical antidepressant effect.
关键词	抑郁症；艾司西酞普兰；白细胞介素；转化生长因子
KeyWord	Depression；escitalopram；interleukin；ransforming growth factor
基金项目
页码	1038-1039

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李露露*. 抑郁症患者治疗前后抗炎性细胞因子的变化分析 [J]. 国际精神病学杂志. 2018; 45; (6). 1038 - 1039.

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