产后抑郁患者血清COR、E2、5-HT及血浆孤啡肽的变化及其意义
Changes of plasma COR, E2, 5-HT and plasma orphanin peptides in patients with postpartum depression and their significance
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2019, 46(3) |
| 作者 |
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| 作者单位 |
濮阳市第三人民医院妇产科，河南濮阳，457000 ;
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| 摘要 |
摘要：探讨产后抑郁与患者血清5-羟色胺（5-HT）、皮质醇（COR）、雌激素（E2）、血浆孤啡肽变化的关系。方法 选取我院2012年12月～2017年12月确诊的产后抑郁患者80例（抑郁组）、选取同期分娩未发生产后抑郁的80例产妇作为对照组，分别检测两组产妇的血清COR、E2、5-HT及血浆孤啡肽水平，并分析上述指标与爱丁堡产后抑郁量表（EPDS）评分的相关关系。结果 抑郁组的血浆孤啡肽水平显著的高于对照组（P<0.05），抑郁组的血清E2、5-HT水平显著的低于对照组（P<0.05），抑郁组和对照组的血清COR水平差异无统计学意义（P>0.05）；抑郁组的血浆孤啡肽水平与EPDS评分呈正相关关系（P<0.05），抑郁组的血清E2、5-HT水平与EPDS评分呈负相关关系（P<0.05），抑郁组血清COR水平与EPDS评分无相关性（P>0.05）；Logistic回归分析：抑郁组的血浆孤啡肽水平升高、血清5-HT水平降低是产妇并发产后抑郁的独立危险因素（P<0.05）。结论 血浆孤啡肽水平升高、血清5-HT水平降低可能导致产妇发生产后抑郁，产后检测这两项指标有利于产后抑郁的早期诊断及干预。
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| Abstract |
Abstract：ObjectiveTo investigate the relationship between postpartum depression and serum serotonin (5-HT), cortisol (COR), estrogen (E2), plasma orphanphin.MethodsA total of 80 cases of postpartum depression (depression group) diagnosed in our hospital (2012.12 ~ 2017.12) and80 cases of postpartum depression with no postpartum depression were selected as control group. Serum COR, E2, and 5-HT were measured in two groups of women. Plasma orphanin levels were analyzed and correlations between the above indicators and the Edinburgh Postpartum Depression Scale (EPDS) score were analyzed.ResultsPlasma orphanin levels in the depressed group were significantly higher than those in the control group (P<0.05). E2 and 5-HT levels in the depressed group were significantly lower than those in the control group (P<0.05). Serum COR in the depressed group and the control group There was no statistically significant difference in levels (P>0.05). There was a positive correlation between plasma orphanin peptide levels and EPDS scores in the depression group (P<0.05). There was a negative correlation between serum E2, 5-HT levels and EPDS scores in the depression group (P<0.05). P<0.05). There was no correlation between serum COR levels and EPDS scores in the depressive group (P>0.05). Logistic regression analysis showed that elevated plasma orphanphin levels and decreased serum 5-HT levels in the depressive group were independent of maternal postpartum depression. Risk factors (P < 0.05).ConclusionElevated plasma orphanphin levels and decreased serum 5-HT levels may lead to maternal postpartum depression, and postpartum testing may facilitate early diagnosis and intervention.
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| 关键词 |
关键词：产后抑郁；5-羟色胺；皮质醇；雌激素；孤啡肽
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| KeyWord |
Key words：Postpartum depression; Serotonin; Cortisol; Estrogen; Orphanin
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| 基金项目 |
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| 页码 |
506-508 |
王彦英*.
产后抑郁患者血清COR、E2、5-HT及血浆孤啡肽的变化及其意义 [J].
国际精神病学杂志.
2019; 46; (3).
506 - 508.