Journal of International Psychiatry

【Abstract】 Objective：To study the changes of serum thyroid hormone levels and related factors in patients with depressive episodes before and after treatment. Methods A total of 70 female patients who were hospitalized in our hospital and met the diagnostic criteria for ICD-10 depressive episodes were enrolled in the observation group. 70 healthy volunteers matched with the observation group were enrolled in the control group. The observation group measured serum thyroid hormone levels at baseline and escitalopram at 4 weeks, and administered 17 Hamilton Depression Rating Scales (HAMD-17) and 14 Hamilton Anxiety Scales (HAMA-14). Baseline thyroid hormone levels were determined. The baseline thyroid hormone levels were compared between the two groups, and the changes in thyroid hormone levels before and after treatment in the observation group. RESULTS: The levels of serum thyroid levels T3, T4, FT3, and FT4 in the baseline observation group were lower than those in the control group (P<0.01, t=1.99, 1.41, 2.47, 3.34). The observation group was treated at 4 weeks compared with baseline. The level of FT4 was increased (P<0.05, t=3.687). The levels of FT3 and FT4 in the observation group were significantly positively correlated with the total scores of HAMA-17 and HAMD-14 (P<0.01). CONCLUSIONS: Abnormal thyroid function in women with depressive episodes may be associated with the severity of the disease, anxiety, and depression.

【Key words】 Depressive episodes Thyroid function Escitalopram Correlation