Journal of International Psychiatry

Objective Observation on clinical curative effect of bupropion hydrochloride sustained-release tablets with naltrexone in treatment of protracted withdrawal syndrome in heroin addicts. Methods 84 heroin addict were randomly assigned into two groups，Bupropion hydrochloride sustained-release tablets with naltrexone (n=42) (the research group)and Naltrexone (n=42) (the control group) for 8 weeks. The effects were assessed with Psychological Craving Scale(PCS) 、Protracted Withdrawal Syndrome Scale(PWSS)、Hamilton anxiety scale(HAMA) and Hamilton depressive scale(HAMD). The changes of electrocardiogram 、biochemical index and were determined before and at the end of treatments to assess the safety.Results At the end of the 8th week, Control group PCS, PWSS、HAMA and HAMD score was with the decreased significantly（P＜0.01）. There were no significant difference between the two groups in electrocardiogram 、biochemical index（P＞0.05）. Conclusion Bupropion Hydrochloride Sustained-Release Tablets can effectively alleviate heroin dependent patients in the mood, such as anxiety, depression, The protracted with protracted withdrawal syndrome in heroin addicts can relieve symptoms .Bupropion hydrochloride sustained-release tablets with naltrexone in treatment of protracted withdrawal syndrome in heroin addicts is a safe and effective treatment.

Bupropion hydrochloride sustained-release tablets；Naltrexone；Protracted withdrawal symptoms