尼麦角林、帕罗西汀联合认知干预对缺血性脑卒中后抑郁患者抑郁状态和炎症因子的影响-国际精神病学杂志-CSCIED科技核心评价数据库-手机版

尼麦角林、帕罗西汀联合认知干预对缺血性脑卒中后抑郁患者抑郁状态和炎症因子的影响

Effects of combination of nimesil and paroxetine on depression and inflammatory factors in patients with post-ischemic stroke

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刊名	国际精神病学杂志 Journal of International Psychiatry
年，卷(期)	2018, 45(6)
作者	樊润润*,胡俊祥,郝永茂,马明明,
作者单位	安阳市第三人民医院神经内科一病区 ;
摘要	【摘要】分析缺血性脑卒中后抑郁患者应用尼麦角林、帕罗西汀联合认知干预治疗后疗效。方法采用随机平行对照法将我院119例缺血性脑卒中后抑郁患者分组，对照组59例应用帕罗西汀联合认知干预治疗，观察组60例增加尼麦角林，对比两组患者治疗后疗效、炎症因子、抑郁状态等变化。结果观察组总有效率90.00%高于对照组76.27%，TNF-α、IL-23、L-6水平及HAMD评分均低于对照组，NE、5-HT、NGF、BDNF水平均高于对照组（P<0.05）。结论帕罗西汀、尼麦角林联合认知干预有效改善缺血性脑卒中后抑郁患者炎症状态，消除抑郁情绪，效果显著。
Abstract	[Abstract] Objective To analyze the efficacy of nigeroline and paroxetine combined with cognitive intervention in patients with post-ischemic stroke. Methods A total of 119 patients with post-ischemic post-stroke depression were enrolled in our hospital. The control group was treated with paroxetine combined with cognitive intervention. The observation group was treated with 60 cases of nigeroline. The therapeutic effect of the two groups was compared. , inflammatory factors, depression status and other changes. Results The total effective rate of the observation group was 90.00% higher than that of the control group (76.27%). The levels of TNF-α, IL-23, L-6 and HAMD were lower than those of the control group. The levels of NE, 5-HT, NGF and BDNF were higher than those of the control group. (P<0.05). Conclusion The combination of paroxetine and nigeroline is effective in improving the inflammatory state of patients with post-ischemic depression and eliminating depression.
关键词	【关键词】尼麦角林；帕罗西汀；认知干预；卒中后抑郁
KeyWord	[Key words] nigralin; paroxetine; cognitive intervention; post-stroke depression
基金项目
页码	1081-1083

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樊润润*,胡俊祥,郝永茂,马明明. 尼麦角林、帕罗西汀联合认知干预对缺血性脑卒中后抑郁患者抑郁状态和炎症因子的影响 [J]. 国际精神病学杂志. 2018; 45; (6). 1081 - 1083.

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