| Abstract |
Objective: To investigate the relationship between blood neutrophil/lymphocyte ratio (NLR) and cognitive function in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: 66 OSAHS patients were divided into mild group (n=16), moderate group (n=15) and severe group (n=35), and 25 healthy subjects were selected as the control group. Polysomnography monitor (PSG) was used to monitor the AHI and LSaO2 of the patients at night. MMSE and MoCA scales were used to evaluate the cognitive function of the patients. The levels of neutrophil/lymphocyte ratio (NLR) in the blood of the 4 groups of subjects were measured. To analyze the correlation between cognitive function scale scores, AHI, LSaO2 and NLR. Results: Compared with the control group, MMSE and MoCA scores of moderate and severe OSAHS groups were decreased. Compared with mild OSAHS group, MMSE and MoCA scores of severe OSAHS group were decreased (P<0.05). OSAHS patients cognitive function (MMSE and MoCA scores) was negatively correlated with AHI (r=-0.472 and -0.768, P<0.05) and positively correlated with LSaO2 (r=0.672 and 0.741, P<0.05). Compared with the control group, the levels of leukocyte, neutrophil and NLR in severe OSAHS group were increased, while those in moderate OSAHS group were increased (P<0.05). Compared with the mild group, the levels of leukocyte, neutrophil and NLR in the severe OSAHS group were all increased (P<0.05). OSAHS patients blood NLR level was positively correlated with AHI (r=0.2594, P<0.05) and negatively correlated with LSaO2 (r=-0.2423, P<0.05). OSAHS patients cognitive function (MMSE and MoCA score) is negatively correlated with NLR (r=-0.3225 and -0.3299, P<0.05). Conclusion: The blood NLR level of OSAHS patients increases with the increase of AHI and the aggravation of hypoxia, and there is a certain correlation between the increase of blood NLR level and the decline of cognitive function. Early screening of OSAHS patients NLR has certain reference value for disease evaluation.
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